Clarmin – indications, contraindications, side effects

Clarmin is an antibacterial drug for systemic use. Macrolide antibiotic used to treat bacterial infections. It is recommended in the treatment of upper and lower respiratory tract infections, pneumonia and folliculitis. The clarithromycin contained in the preparation has a bacteriostatic effect. The drug is obtained by prescription in the form of film-coated tablets.

Klarmin, Producer: ICN Polfa Rzeszów / Valeant

Indications for taking Klarmin

The active substance of Clarmin is clarithromycin. The preparation is used in the treatment of the following infections caused by microorganisms sensitive to clarithromycin:

1. upper respiratory tract, sinus and middle ear infections,
2. lower respiratory tract infections (e.g. bronchitis, bacterial pneumonia, atypical pneumonia),
3. skin, subcutaneous and soft tissue infections (e.g. contagious impetigo, folliculitis, furunculosis, erysipelas, wound infections), disseminated or localized mycobacterial infections.
4. Treatment of infections Helicobacter pylori in people with duodenal ulcer (in combination with other drugs).
5. In HIV-infected patients: prevention of disseminated mycobacterial infections (by the MAC complex).
6. Additionally, the preparation in the form of 250 mg film-coated tablets is indicated: in the treatment of infections of the teeth and mouth (periapical abscess, periodontitis).

Klarmin – contraindications

1. Hypersensitivity to any component of Klarmin or other macrolide antibiotics.
2. During treatment with clarithromycin, the use of any of the following drugs is contraindicated: astemizole, cisapride, pimozide, terfenadine, ergotamine or dihydroergotamine.

Dosage

Adults and children over 12 years of age: the recommended dose in the treatment of infections of the respiratory tract, skin and soft tissues is 250 mg twice a day (every 2 hours); in severe infections, your doctor may increase the dose to 12 mg twice a day (every 500 hours). The treatment duration is 2-12 days, and in the treatment of pneumonia and sinusitis, it is 5-14 days.

1. In patients with renal insufficiency (creatinine clearance less than 30 ml / min), it is necessary to adjust the dosage by the doctor (usually the doctor will reduce the dose by half). In this group of patients, the drug should not be used for more than 14 days.
2. Infections of the teeth and mouth (only for the preparation in the form of 250 mg film-coated tablets): 250 mg twice a day (every 2 hours). Treatment usually takes 12 days.
3. Infections caused by mycobacteria: adults 500 mg twice a day (every 2 hours). Treatment of disseminated infections in AIDS patients should be continued as long as a clinical benefit is observed (concomitant therapy).
4. Prevention of infections caused by mycobacteria MAC in adults: 500 mg twice a day (every 2 hours).
5. Infections Helicobacter pylori (treatment in combination with other drugs): 500 mg 2-3 times a day for 7-14 days, depending on the prescribed treatment regimen.

Klarmine – warnings

1. Caution should be exercised when using Clarmin in people with hepatic insufficiency and in people with moderate or severe renal insufficiency.
2. Concomitant administration of clarithromycin and colchicine with the drug may lead to increased toxicity of colchicine and sometimes lead to death, especially in elderly patients or with renal insufficiency.
3. If diarrhea occurs during or after treatment with Klarmin, do not treat it yourself, but consult a doctor.
4. Clarmin has no influence on the ability to drive and use machines, however, this medicine may cause side effects such as dizziness, confusion, disorientation, which may impair the ability to drive and use machines / machines.
5. Pregnant women should consult a doctor before taking the drug, because he has data on the safety of its use in this group of women.
6. The clarithromycin contained in the preparation passes into breast milk.

Klarmin – interactions

Tell your doctor if you are taking:

1. drugs metabolized with the participation of the cytochrome P3 isoenzyme 450A, such as: alprazolam, astemizole, cilostazol, cisapride, cyclosporine, disopyramide, ergot alkaloids (e.g. ergotamine), carbamazepine, lovastatin, methylprednisolone, midazolam, omeprazole, oral medications (e.g., anteprazole). pimozide, quinidine, rifabutin, sildenafil, tadalafil, vardenafil, simvastatin, tacrolimus, terfenadine, triazolam, vinblastine;
2. drugs that increase the activity of the cytochrome P3 450A isoenzyme, such as: rifampicin, rifabutin, rifapentine, phenytoin, carbamazepine, phenobarbital, St. John’s wort preparations, efavirenz, nevirapine;
3. drugs reducing the activity of the cytochrome P3 450A isoenzyme such as: ritonavir, nelfinavir, itraconazole, fluconazole;
4. drugs that can prolong the QT interval on the ECG (including antiarrhythmic drugs such as disopyramide, quinidine, amiodarone);
5. phenytoin, theophylline, valproinian;
6. ergot alkaloids (ergotamine, dihydroergotamine);
7. omeprazole;
8. anticoagulants (e.g., warfarin);
9. benzodiazepine derivatives (midazolam, triazolam, alprazolam);
10. digoxin;
11. kolchicynę;
12. anti-retroviral drugs (e.g. zidovudine, ritonavir).

Clarmine – side effects

They may appear, among others: neutropenia (reduction in the number of neutrophils or neutrophils), muscle and joint pain, cholestatic jaundice, liver necrosis and liver failure, nausea, vomiting, diarrhea, abdominal pain, flatulence, digestive disorders, glossitis, tooth discoloration that can be cleaned by a dentist, inflammation mouth, hives, skin eruption, angioedema (possible swelling of the lips, tongue, throat, larynx making it difficult to breathe), anaphylactic shock and severe skin reactions such as Stevens-Johnson syndrome.