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There are many methods of contraception, one of which is the use of oral hormone therapy. There are prescription preparations available on the market that contain one or two ingredients. They are synthetic derivatives of progesterone and estrogens. Cerazette is an oral, single-component form of hormonal contraception that is safe for lactating women. How does Cerazette work? What are the possible side effects of taking this medication?
Most preparations intended for oral hormone therapy contain two active ingredients. One is a derivative of progesterone and the other is an estrogen. These are hormones the intake of which stops ovulation (ovulation), which prevents the egg from maturing. This, in turn, prevents pregnancy. However, not every woman adequately tolerates two-component preparations intended for oral hormone therapy due to the presence of estrogen derivatives. Taking this fact into account, one-component agents were developed, the only active substance of which are synthetic drugs with progesterone activity. One of such compounds is XNUMXrd generation gestagen – desogestrel contained in Cerazette.
Cerazette – action
Cerazette is a single ingredient preparation, the active substance of which is a gestagenic compound, desogestrel. The mechanism of action of the drug is based on the inhibition of the secretion of luteinizing hormone, abbreviated as LH. This substance is released from the anterior pituitary gland and is responsible for the rupture of the Graaf follicle and the release of the egg. The inhibition of the secretion of lutropin by the active substance contained in Cerazette counteracts this process. In addition, desogestrel thickens the cervical mucus, making it cloudy and sticky. It is referred to as the so-called gestagenic (infertile) mucus that makes it difficult for sperm to reach the egg. Taking Cerazette lowers estradiol levels. The preparation has a low androgenic activity, which means that it does not have a strong effect on ovulation arrest, which is why it is not 0,4% effective as a contraceptive (ovulation may occur despite the use of the drug). The Pearl Index for the desogestrel in Cerazette is XNUMX.
Cerazette – indications for use
The indication for the use of Cerazette is hormonal contraception. The active ingredient of the drug does not pass into breast milk, which makes it a compound that can be safely used by lactating women. In such a situation, the use of two-component preparations (containing estrogens) is contraindicated due to the risk of inhibition of the lactation process. Cerazette is also indicated as a contraceptive for women who do not want to take or are hypersensitive to two-component preparations containing estrogens.
Cerazette – dosage
Cerazette should be taken once a day and always at the same time each day. Time deviations should not exceed +/- 3 hours. Take the tablets in the direction of the arrows on the blisters. The starting dose should be taken on the first day of the period. If Cerazette was used between days 2 and 5 of the menstrual cycle, then an additional barrier form of contraception is required due to the possible reduced effectiveness of the drug. In the case of lactating women, treatment with desogestrel should commence approximately three weeks after delivery. If you miss a dose, take the medicine and then continue treatment as before. The effectiveness of Cerazette may be reduced when there is more than 36 hours between taking two consecutive doses.
Cerazette – contraindications
Desogestrel should not be taken in case of: hypersensitivity to this compound, thromboembolism, cancer, severe liver diseases and vaginal bleeding of unknown etiology, pregnancy.
Cerazette – interactions
Cerazette may cause drug interactions that increase hepatic metabolism. These are, for example: anticonvulsants (phenytoin, oxcarbazepine, phenobarbital, topiramate), antiviral drugs (ritonavir, nelfinavir), as well as preparations based on St. John’s wort. Reduction of drug absorption also occurs with the simultaneous use of activated charcoal.
Cerazette – warnings
Contraceptives may increase the risk of breast cancer. However, the risk is less with Cerazette than with combined (combined) contraceptive pills.
Cerazette – side effects
The most common side effect with Cerazette is irregular monthly bleeding. This applies to about 50 percent. female patients. However, after a few months of therapy, this condition is corrected. Other potential side effects include acne, mood swings, breast soreness, nausea, and increased appetite.
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