The C-terminal propeptide of type I procollagen is a marker protein of the bone formation process.
This peptide is formed during the extracellular synthesis of collagen from procollagen – a structural component of bone tissue.
When do we do?
1. Skeletal disorders (osteoporosis, pathological fractures, skeletal deformities, calcium-phosphate disturbances).
2. Metabolic diseases of bone tissue (Paget’s disease, adynamic bone disease).
3. Increased bone turnover (hyperparathyroidism, hypercalcemia, hyperthyroidism).
Test material: serum.
Preparation for the test: on an empty stomach (at least 8 hours).
The course of the study: one-time blood sampling from a vein in the arm.
Time to wait for the result: 1 Day.
Standard: 30-200 µg/l.
Comments: Increased concentration of bone markers may be the result of an increase in the number of bone remodeling sites, extension of the bone formation phase in remodeling units or the activation of bone formation processes in various sites of remodeling (on the surface of the trabeculae, on the surface of the cortical bone from the side of the marrow cavity, on the subperiosteal surface of the cortex). The PICP level reflects the number of newly formed collagen molecules. In addition to bones, it is also produced in other tissues where type I collagen is synthesized.