Def .: Generalized brown or gray color of the skin of newborns undergoing phototherapy due to elevated blood bilirubin levels.
Etiol. and Pat .: The cause of the changes is the deficiency of biliverdin reductase, which is responsible for the metabolism and excretion of the excess pigment. During 1-3 days of phototherapy, non-toxic products of bilirubin photooxidation or porphyrin metabolism products accumulate in the skin. Porphyrins contain copper, which directly contributes to discoloration.
Clinical: Discoloration is generalized with a shade of brown. They disappear spontaneously after the end of irradiation.
DL: Serum and urine also become discolored.
Year: Good
Source: A. Kaszuba, Z. Adamski: “Lexicon of dermatology”; XNUMXst edition, Czelej Publishing House