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Biofazolin is a beta-lactam antibiotic that is used in patients diagnosed with a bacterial infection. The main active ingredient is cefazolin. How it works? We check for which diseases the doctor can prescribe Biofazolin.
Biofazolin – application
Biofazolin works best for conditions caused by bacteria that are sensitive to cefazolin. It is about diseases such as:
- sepsis;
- respiratory tract infection;
- genitourinary tract infection;
- skin and soft tissue infection;
- biliary tract infection;
- bone and joint infection;
- endocarditis.
Additionally, Biofazolin is used in patients with perioperative infections. This applies especially to departments: cardiosurgery, orthopedics, gynecology, obstetrics, as well as liver and gallbladder surgery.
Biofazolin – how does cefazolin work?
Cefazolin is a semi-synthetic antibiotic which is the main constituent of Biofazolin. Thanks to it, bacterial cell walls cannot be synthesized, which prevents their further multiplication in the body. Cefazoline is one of the beta-lactam antibiotics due to its chemical composition.
Cefazoline can only be administered intramuscularly or intravenously.
Biofazolin – dosage
The preparation is available at the pharmacy in the form of a powder to be administered intravenously (infusion) or intramuscularly to the patient. Dosage details for specific diseases are as follows:
- pneumococcal pneumonia – 500 mg / 12 hours;
- sepsis and endocarditis – 1-1,5 g / 6 hours;
- genitourinary system infection – 1g / 12 hours;
- moderate infection caused by Gram-positive bacteria – 250-500 mg / 8 hours;
- moderate or severe infection – 0,5-1 g / 6-8 hours.
Children can take 25-50 mg for every kilogram of body weight. Dosing usually lasts 2-3 days until symptoms improve.
Biofazolin – side effects
The most common side effects after using Biofazolin include:
- diarrhea;
- nausea;
- stomach pain;
- lack of appetite;
- itching;
- rash;
- maculopapular erythema;
- hives;
- headaches;
- oral candidiasis;
- vaginal candidiasis;
- transient changes in the blood picture;
- thrombophlebitis (occurs rarely, only with intravenous administration of Biofazolin).
Biofazolin – precautions
Before administering Biofazolin, the doctor conducts an interview with the patient. It is worth informing him about penicillin hypersensitivity so that he does not experience an anaphylactic reaction after starting intravenous or intramuscular treatment. Some patients may develop diarrhea caused by pseudomembranous colitis and you should inform your doctor about this.
Biofazolin – use in pregnant women and nursing mothers
Pregnant women may use Biofazolin only in life or health-threatening situations. Breastfeeding mothers must be careful when dosing the drug as it may cause diarrhea, thrush or an allergy in the newborn.
Biofazolin – interactions with other drugs
Biofazolin should not be combined with drugs such as:
- diuretics;
- anticoagulants;
- aminoglycoside antibiotics;
- samplesecyd.
In addition, Biofazolin may falsify the results of studies, including Coombs’ tests.
Before use, read the leaflet, which contains indications, contraindications, data on side effects and dosage as well as information on the use of the medicinal product, or consult your doctor or pharmacist, as each drug used improperly is a threat to your life or health.