Contents
Cattle get sick often, because most viral infections are transmitted through the air. Bicillin for cattle (Bicillin) is a bactericidal antibiotic that prevents the appearance of peptide bonds, stops chemical reactions involving cell wall peptidoglycan in the early, late stages.
Features of the use of bicillin for cows and calves
A tasteless, odorless crystalline powder of white or slightly yellow color is used for the preparation of injection solutions. Bicillin for cattle is diluted immediately before the injection according to the manufacturer’s instructions. To create a solution use:
- saline, aka sodium chloride solution;
- sterile water for injection.
Composition and form of release
Manufacturers supply bicillin for cattle in convenient glass bottles with a total capacity of 10 ml. The biological activity of the drug is determined in units of action of the active substance. It is equal to 1307 IU / mg. On the bottle of the drug “Bicillin” you can read the release date, active ingredients, the name of the manufacturer.
The substance is practically insoluble in water, loses activity when exposed to:
- acids or substances containing their components;
- oxidizers;
- alkaline solutions;
- the enzyme penicillin.
Manufacturers produce:
- Bicillin-1 – in the composition of benzathine benzylpenicillin. Bottles of powder 300, 600, 1200 thousand units of 10 and 20 ml. White powder, odorless, taste, prone to clumping during long-term storage. With water, saline forms a stable suspension.
- Bicillin-3 – in the composition of benzathine benzylpenicillin, benzylpenicillin novocaine salt, sodium benzylpenicillin. Powder bottles 300, 600, 900, 1200 thousand units, 10 ml each. Powder of white or slightly yellow color, prone to churning into lumps during prolonged storage, which turns into a milky suspension when liquid is added.
- Bicillin-5 – in the composition of benzathine benzylpenicillin, benzylpenicillin novocaine salt. Vials of the substance 1500 thousand units, 10 ml each. White powder, may form lumps during long-term storage, odorless, has a bitter taste. When adding water, saline solution forms a cloudy homogeneous suspension.
Pharmacological properties
A natural antibiotic of the penicillin group for cattle actively prevents the growth, spread, reproduction of gram-positive microorganisms:
- pneumococci;
- Staphylococcus spp., other than those producing penicillinase
- Clostridium;
- Streptococcus spp., including Streptococcus pneumoniae;
- anthrax sticks;
- Corynebacterium diphtheriae;
- Bacillus anthracis.
Bicillin for cattle has increased bactericidal properties and antibacterial action, prevents the reproduction of some gram-negative microbes:
- Neisseria gonorrhoeae;
- Neisseria meningitidis;
- Аctinomyces israelii;
- Treponema spp.;
- anaerobic spore-forming rods.
Bicillin-1 for cattle, it is gradually absorbed into the body, due to which it enters the blood for a long time, it begins to act after 4 hours. The maximum concentration reaches in 12 – 24 hours.
Bicillin-3 for cattle it is slowly hydrolyzed. With a single injection, the concentration in the blood sufficient for treatment is maintained for 6-7 days.
Bicillin-5 for cattle is the most effective in the fight against serious diseases. Reaches maximum concentration in an hour. The desired level of penicillin is observed in the body 28 days after the first injection of bicillin in cattle. The components of the drug penetrate into milk, so it is not recommended to use it for food purposes.
Indications for use
Bicillin for cattle is used for the treatment and prevention of many diseases caused by penicillin-sensitive microorganisms. Among them:
- salmonellosis;
- pasteurellosis;
- bronchopneumonia;
- inflammation of the ovaries, oviducts;
- necrobacteriosis;
- mastitis;
- metritis;
- wound infection;
- otitis;
- urinary tract infection;
- septicemia;
- actinomycosis;
- emphysematous carbuncle;
- streptococcal septicemia.
The effectiveness of bicillin for cattle depends on the dosage that the specialist must select. It determines the number of units administered, the regularity of injections. If cattle do not have individual sensitivity to the components, then bicillin injections begin with a double dose, which is considered a shock.
The course of treatment is 7 days. In severe diseases, the veterinarian may prescribe a 14-day intake of the drug. Bicillin for cattle can be used as a powder for disinfecting external wounds, accelerating their healing.
Противопоказания
Bicillin is not allowed to enter cattle with hypersensitivity to drugs of the penicillin group. This may cause unwanted side effects. Veterinarians do not recommend the substance to animals that do not tolerate novocaine.
Dosage and administration for cattle
Bicillin is administered only intramuscularly, inserting the needle to a greater depth. The solution is prepared before injection according to the manufacturer’s instructions. Bicillin-5 is administered to a cow to create a high level of penicillin concentration in the body for a long time.
For adult animals, a single dosage is calculated according to the formula: 10 thousand units for each kilogram of weight. This allows you to raise the concentration of penicillin in the blood to 4 μg / ml, which slowly drops to 0,09 μg / ml during the day.
The dose of Bicillin-3 for cattle – 100 thousand units per kilogram of weight raises the level of the active substance in the blood to 3,8 μg / ml, gradually decreasing to 0,12 μg / ml during the day. Studies have shown that penicillin remains in the proportion of 0,12 – 0,06 μg / ml for another 4 – 5 days.
Bicillin-5 calves are injected with 15 thousand units for each kilogram of weight. The antibiotic is quite powerful, penetrates into all organs. Analyzes showed the presence of bicillin components in the lungs, muscles, blood of cattle. For adults, the dosage is calculated according to the standard formula.
Side effects
Bicillin cattle is well received, but there are exceptions. The introduction of the drug can cause the appearance of:
- lethargy;
- drowsiness;
- vomiting;
- allergies;
- diarrhea.
If these reactions occur after an injection of cattle bicillin, you should contact your veterinarian. The most dangerous side effect is an allergic reaction. In order to protect cattle, an adequate amount of antihistamines should be kept in reserve when bicillin is first administered.
Interaction with other drugs
Information about a decrease in the activity of other drugs, an increase in side effects from them was not found. Bitsillin does not affect digestion, lactation, and the work of the heart of cattle. It is allowed to combine the drug with globulins, streptomycin, specific sera and sulfa drugs. It is not recommended to combine with antibiotics based on chloramphenicol or tetracycline.
You can kill cattle for meat no earlier than 14 days have passed since the last injection of bicillin. If it was necessary to slaughter before this period, then people should not be given meat for food, only carnivorous animals. Milk from cattle during the period of use of the drug and 10 days after it should not be consumed, but it can be given to mammals after heat treatment.
Shelf life and storage conditions
Bicillin for cattle is hidden away from children and animals. It is necessary to store the drug with great care, according to list B. The bottle must be sealed by the manufacturer, open containers must be thrown away immediately. The storage place must be dry, without access to ultraviolet rays. The recommended temperature is from +10 to +20 degrees. The shelf life is counted from the date of manufacture and is 3 years.
Conclusion
Bicillin for cattle contains benzylpenicillin salts with antibacterial action, they inhibit the synthesis of microorganism cells. Animals tolerate the drug well, with the exception of those who have individual intolerance to the components. The dosage of the drug, the number of repetitions and the duration of injections are determined by the veterinarian.