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Bi-Profenid is a drug in the form of modified-release tablets with analgesic, anti-inflammatory and antipyretic applications. It belongs to the group of NSAIDs – non-steroidal anti-inflammatory drugs. Modified-release means that the tablets have two layers: fast and slow release of the active ingredient.
The active ingredient of Bi-Profenid is ketoprofen; a tablet of the drug contains 150 mg of this substance. A package of 20 pieces costs about PLN 13. The other ingredients are lactose monohydrate, wheat starch, hydrated silica, gelatin, magnesium stearate, hydroxyethyl cellulose, aqueous calcium hydrogen phosphate, and riboflavin sodium phosphate.
Bi-Profenid is widely used: it is involved in the symptomatic treatment of rheumatic diseases, including rheumatoid arthritis (RA), arthritis of other etiology, other inflammatory conditions and osteoarthritis.
Dosage of the drug Bi-Profenid
The dose of each drug should be determined by a physician based on an in-depth analysis and adjusted to the individual needs of the patient. In the case of long-term treatment, the standard dose is 150 mg of the active ingredient as one tablet once a day; the dose can also be split into two tablet halves to be taken at different times of the day.
For the short-term treatment of an acute condition, a dose of 300 mg per day may be recommended. 300 mg per day is also the maximum dose. It should be remembered that taking the drug minimally reduces the risk of side effects. A forgotten dose should not be made up for a later double dose.
Bi-Profenid – contraindications and warnings
Pregnant women can take Bi-Profenid only as a last resort, after consulting a doctor, and only in the first and second trimesters. The preparation is also not recommended for women during breastfeeding. The drug is also not suitable for children under 15 years of age. Ketoprofen may cause dizziness, somnolence and visual disturbances, so if you experience these effects, you should avoid driving until consulting your doctor. Caution is advised when using this drug in elderly patients with intestinal and liver disorders and heart failure. Due to the presence of wheat starch, people with hypersensitivity or intolerance to gluten should be careful.
Bi-Profenid – possible side effects
Taking Bi-Profenid may be associated with numerous side effects. These are i.a. nausea, vomiting, diarrhea, dyspepsia, abdominal pain, gastritis, gastric or duodenal ulcer, gastrointestinal bleeding, intestinal perforation, dyspnoea, anaphylactic reactions, dizziness, paraesthesia, convulsions, intestinal failure and leukopenia.
Bi-Profenid – interactions with other drugs
Bi-Profenid should not be taken simultaneously with many groups of drugs. They include, among others other NSAIDs, anticoagulants, lithium and methotrexate. Caution should be exercised when taking, inter alia, also corticosteroids, diuretics, pentoxifylline, cardiac glycosides and quinolone antibiotics.
| Name of the drug / preparation | Bi-Profenid |
| Wstęp | Bi-Profenid is a drug with analgesic, anti-inflammatory and antipyretic properties. It belongs to the group of NSAIDs |
| Manufacturer | Sanofi Aventis |
| Form, dose, packaging | Tablets, 150 mg of active ingredient; 20 pcs |
| Availability category | Prescription drug |
| The active substance | ketoprofen |
| Indication | Symptomatic treatment of rheumatic diseases |
| Dosage | 1 tablet a day for long-term treatment 2 tablets a day for short-term treatment. |
| Contraindications to use | Many; incl. pregnancy, feeding, allergy to any ingredient, diseases of the gastrointestinal tract, heart, liver or kidney diseases, coagulation disorders, bleeding |
| Warnings | Many; incl. the drug is not intended for children under 15 years of age; driving is not recommended as the drug may cause visual disturbances; recommended caution in elderly patients |
| Interactions | Many medications should not be taken with Bi-Profenid, including lithium, methotrexate, anticoagulants, and other NSAIDs |
| Side effects | Many; incl. nausea, vomiting, diarrhea, dyspepsia, abdominal pain, gastritis, peptic ulcer disease, gastrointestinal bleeding, intestinal perforation, dyspnoea, anaphylactic reactions, dizziness, paresthesia, convulsions, intestinal failure, leukopenia. |
| Other (if any) | x |