Bestpirin – indications, dosage, contraindications, side effects

Bestpirin is a drug used in the treatment of fever in the course of colds and flu, as well as pain of mild to moderate intensity. The preparation inhibits the aggregation of platelets. The active substance is acetylsalicylic acid, which has anti-inflammatory, analgesic and antipyretic properties. The drug is in the form of coated tablets and is available without a prescription.

Bestpirin (Teva Pharmaceuticals Polska)

ACTION

Bestpirin is a non-steroidal anti-inflammatory drug.

Bestpirin – indications and dosage

Bestpirin are coated tablets recommended for taking:

1. during a fever in the course of a cold or flu,
2. for headaches,
3. and nerwobóle,
4. for muscle and joint pain.

Drug dosage

Bestpirin is in the form of film-coated tablets intended for oral use. The drug should be taken preferably after meals, swallowing the tablet whole with plenty of water.

1. Adults: usually 1-2 tablets once, the dose can be repeated 2-3 times / day.
2. Adolescents after the age of 12 1-2 tablets / day, dose max. 1,5 g / day.

Bestpirin and contraindications for taking

There are the following contraindications to the use of Bestpirin:

1. allergy to any ingredient of the preparation,
2. active stomach or duodenal ulcer,
3. hemorrhagic diathesis,
4. bronchial asthma attacks or a history of allergic rhinitis with polyps of the nasal mucosa, caused by administration of salicylates or other non-steroidal anti-inflammatory drugs,
5. simultaneous use of methotrexate at a dose of 15 mg / week or more,
6. pregnancy,
7. the period of breastfeeding,
8. use in children up to 12 years of age, especially in the course of viral infections (risk of Reye’s syndrome).

Bestpirin – warnings

1. Bestpirin should be used with caution in the following cases: stomach ulcer, simultaneous intake of anticoagulants, renal or hepatic dysfunction, hypertension, dehydration, deficiency of glucose-6-phosphate dehydrogenase, hypersensitivity to anti-inflammatory drugs.
2. Due to its anti-aggregating effect, the acetylsalicylic acid contained in the drug may extend the bleeding time during and after surgery (also in the case of minor procedures, e.g. tooth extraction). Acetylsalicylic acid can also cause bronchospasm, asthma attacks and other allergic reactions, especially in patients with bronchial asthma, chronic urinary tract diseases, hay fever or nasal polyps. This note also applies to people who show allergic reactions in the form of skin reactions, itching or hives to other substances.
3. The use of even low doses of acetylsalicylic acid may reduce the excretion of uric acid from the body.
4. Patients with decreased uric acid excretion Acetylsalicylic acid may cause gout.
5. Patients who have difficulty emptying the stomach rarely have one or more tablets remaining in the stomach. The tablets that remain in the stomach may form a conglomerate due to clumping of the shells (this may cause reflex vomiting).
6. If you are taking Bestpirin before taking ibuprofen, see your doctor.
7. Preparations that block prostaglandin synthesis may impair female fertility, this effect is transient and concerns acetylsalicylic acid taken at a dose of 500 mg per day or more.

Bestpirin with other drugs

1. Acetylsalicylic acid contained in Bestipirin increases the toxicity of methotrexate on the bone marrow (do not use acetylsalicylic acid simultaneously with methotrexate used in doses of 15 mg per week or more; concomitant use of methotrexate in doses lower than 15 mg per week requires special care).
2. In people at increased risk of cardiovascular events, treatment with ibuprofen may reduce the cardioprotective effect of acetylsalicylic acid.
3. Concomitant use of acetylsalicylic acid with anticoagulants may intensify the anticoagulant effect: increased risk of prolonged bleeding time and haemorrhages, resulting from the displacement of anticoagulants from their plasma protein connections and the anti-aggregating properties of acetylsalicylic acid.
4. Concomitant use of non-steroidal anti-inflammatory drugs with acetylsalicylic acid increases the risk of gastric and / or duodenal ulcer disease and gastrointestinal bleeding and kidney damage, due to the synergistic effect of these drugs.
5. Acetylsalicylic acid, when used simultaneously with drugs that increase uric acid excretion (benzbromarone, probenecid), reduces the effect of drugs used in the treatment of gout.
6. Concomitant administration of acetylsalicylic acid with digoxin increases the plasma concentration of digoxin.
7. Due to its hypoglycaemic properties and displacement of sulfonylureas from plasma protein connections, acetylsalicylic acid enhances the effect of antidiabetic drugs (e.g. insulin, sulfonylureas).
8. Thrombolytic drugs or other drugs that inhibit platelet aggregation (e.g. ticlopidine) when used concomitantly with acetylsalicylic acid may increase the risk of prolonged bleeding time and haemorrhage.
9. Acetylsalicylic acid reduces the effect of diuretics.
10. Acetylsalicylic acid may increase the ototoxicity of furosemide.
11. Systemic glucocorticosteroids (except hydrocortisone administered as replacement therapy in Addison’s disease) with acetylsalicylic acid increase the risk of gastric and / or duodenal ulcer disease, gastrointestinal bleeding, and decrease plasma salicylate levels during corticotherapy and increase the risk of overdose with salicylates after discontinuation. taking glucocorticosteroids.
12. ACE inhibitors reduce the antihypertensive effect when used simultaneously with high doses of acetylsalicylic acid.
13. Acetylsalicylic acid increases the toxic effect of valproic acid by displacing it from its connections with plasma proteins.
14. Valproic acid increases the effect of acetylsalicylic acid due to the synergistic anti-aggregation effect of both drugs.
15. Alcohol can increase the risk of gastrointestinal side effects such as mucosal ulceration or bleeding.

Bestpirin – side effects

The use of Bestpirin causes the following side effects:

1. symptoms of indigestion (heartburn, nausea, vomiting), abdominal pain, rarely inflammation of the stomach and intestines may appear; gastric and / or duodenal ulcer disease (very rarely leading to haemorrhage and perforation with appropriate laboratory and clinical changes),
2. Transient hepatic abnormalities with elevated transaminase levels, dizziness and tinnitus, which are usually symptoms of overdose, have been reported rarely. Increased risk of bleeding, prolonged bleeding time, prothrombin time, thrombocytopenia. Bleeding such as: perioperative haemorrhage, hematomas, epistaxis, urogenital bleeding, gingival bleeding,
3. rarely or very rarely, serious bleeding such as gastrointestinal haemorrhage, cerebral haemorrhage (especially in patients with uncontrolled hypertension and / or in the case of concomitant administration of drugs that inhibit bleeding), which may be potentially life-threatening in isolated cases, has been reported. Haemorrhage can lead to acute or chronic anemia due to haemorrhage and / or iron deficiency anemia (e.g. from latent microbleeding) with appropriate laboratory and clinical signs such as weakness, paleness, hypoperfusion,
4. Rarely, papillary necrosis and interstitial nephritis have occurred after long-term use of high doses of acetylsalicylic acid. Hypersensitivity reactions with relevant laboratory and clinical signs including: asthma, skin reactions, rash, urticaria, edema, pruritus, cardio-respiratory disorders. Very rarely severe reactions including anaphylactic shock,
5. very rarely hypoglycaemia,
6. long-term use of drugs containing acetylsalicylic acid may cause a headache, which worsens with subsequent doses. Long-term use of painkillers, especially those containing several active substances, can lead to severe renal impairment and kidney failure.