Bestpirin 75 mg

Bestpirin 75 mg is a drug that inhibits platelet aggregation, prevents myocardial infarction and is used in the prevention of transient ischemic attacks (TIA) and ischemic stroke. The drug is in the form of gastro-resistant tablets, and thanks to a special coating, it dissolves only around the duodenum and small intestine. The preparation is available without a prescription.

Bestpirin (Teva Pharmaceuticals Polska)

Action

Bestpirin 75 mg is a preparation that inhibits platelet aggregation (prevents platelets from sticking together, which may lead to blood clots). The tablets are resistant to gastric juices, and thanks to the secretion of acetylsalicylic acid, irritation of the gastric mucosa is reduced.

Bestpirin 75 mg indications and dosage

Bestpirin 75 mg is a drug used in:

1. prevention of a heart attack and prevention of a repeat heart attack,
2. ischemic heart disease,
3. prevention of transient ischemic attacks (TIA) and ischemic stroke in patients with TIA.

Dosage

Bestpirin 75 mg is a gastro-resistant tablet and should be taken orally (whole), preferably after a meal with plenty of water. If you miss a dose, wait and take the next dose when it is due.

1. Adults. Usually 75 mg (1 tablet) once a day.
2. Adults. Usually 150 mg (2 tablet) once a day.

Bestpirin 75 mg – contraindications to use

Contraindication to the use of Bestpirin 75 mg are:

1. hypersensitivity to any component of the preparation,
2. active stomach or duodenal ulcer,
3. hemorrhagic diathesis,
4. bronchial asthma attacks or a history of allergic rhinitis with polyps of the nasal mucosa, caused by administration of salicylates or other non-steroidal anti-inflammatory drugs,
5. simultaneous use of methotrexate at a dose of 15 mg / week or more,
6. pregnancy, breastfeeding,
7. severe heart, liver or kidney failure.
8. do not use in children under 12 years of age, especially in the course of viral infections due to the risk of Reye’s syndrome.

Bestpirin 75 mg – warnings

1. The drug should be used with caution in people with gastric and / or duodenal ulcers.
2. Patients concomitantly taking anticoagulants should exercise caution.
3. People with renal or hepatic impairment, hypertension, dehydration and deficiency of glucose-6-phosphate dehydrogenase, and hypersensitivity to anti-inflammatory drugs should be especially careful.
4. The acetylsalicylic acid contained in the drug may lead to an increase in bleeding time during and after surgery.
5. Bestpirin may cause bronchospasm and asthma attacks or other allergic reactions. Patients with bronchial asthma, chronic respiratory disease, allergic rhinitis (hay fever) or nasal polyps are at particular risk.
6. Patients who are prone to allergic reactions (e.g. pruritus, hives, skin reactions) to other medications should be careful.
7. The drug acetylsalicylic acid, even taken in low doses, reduces the excretion of uric acid from the body.
8. The drug can lead to gout in patients who have reduced uric acid excretion.
9. One or more tablets may remain in the stomach (very rarely) in patients with bowel problems. The tablets may conglomerate due to clumping of the shells, and you may experience fullness in your stomach and even vomit.
10. The drug may cause skin irritation due to the content of cochineal red and propylene glycol.

Bestpirin 75 mg with other drugs

1. Use with acetylsalicylic acid causes bone marrow toxicity of methotrexate. They should not be used simultaneously in doses of 15 mg per week or more. Use in doses less than 15 mg per week requires caution.
2. Treatment with ibuprofen may reduce the cardioprotective effect of acetylsalicylic acid in patients at increased risk of cardiovascular disease.
3. Use with anticoagulants enhances the anticoagulant effect and may prolong bleeding and haemorrhage times.
4. Concomitant use with non-steroidal anti-inflammatory drugs poses a risk of gastric or duodenal ulcer disease, as well as gastrointestinal bleeding and kidney damage due to the synergistic interaction of these drugs.
5. Acetylsalicylic acid reduces the effect of drugs used in the treatment of gout, if it is used simultaneously with preparations that increase the excretion of uric acid (e.g. benzbromarone, probenecid).
6. Concomitant administration of acetylsalicylic acid with digoxin leads to an increase in the plasma digoxin concentration.
7. Acetylsalicylic acid increases the effect of antidiabetic drugs (e.g. insulin, sulfonylureas) because it has hypoglycemic properties and displaces sulfonylureas from plasma protein connections.
8. The use of thrombolytic drugs or other drugs that inhibit platelet clumping (e.g. ticlopidine) together with acetylsalicylic acid may prolong bleeding and haemorrhage times.
9. The preparation reduces the effect of diuretics.
10. The ototoxicity of furosemide may be increased by acetylsalicylic acid.
11. Systemic glucocorticosteroids (with the exception of hydrocortisone used as replacement therapy in Addison’s disease) in combination with the drug may lead to gastric or duodenal ulcer disease, gastrointestinal bleeding, and reduce plasma salicylate levels during corticotherapy and increase the risk of salicylate overdose upon discontinuation of glucocorticosteroids.
12. Concomitant use of angiotensin converting enzyme inhibitors in large doses with acetylsalicylic acid reduces the antihypertensive effect.
13. Valproic acid enhances the effect of acetylsalicylic acid, while acetylsalicylic acid increases the toxic effect of valproic acid.
14. Concomitant use with alcohol increases the risk of, for example, mucosal ulceration or bleeding.

Bestpirin 75 mg – side effects

When using Bestpirin 75 mg

1. symptoms of indigestion (heartburn, nausea, vomiting), abdominal pain, rarely inflammation of the stomach and intestines may appear; gastric and / or duodenal ulcers very rarely leading to haemorrhage and perforation with appropriate laboratory and clinical changes.
2. Transient hepatic impairment with elevated transaminases has been rarely reported. Dizziness and tinnitus, usually symptoms of overdose. Increased risk of bleeding, prolonged bleeding time, prothrombin time, thrombocytopenia. Bleeding events such as perioperative haemorrhage, hematomas, epistaxis, urogenital bleeding, and gingival bleeding have been observed.
3. Rarely or very rarely, serious bleeding such as gastrointestinal haemorrhage, cerebral haemorrhage (especially in patients with uncontrolled hypertension and / or in the case of concomitant administration of drugs that inhibit bleeding) have been reported, which may be potentially life-threatening in isolated cases. Haemorrhage can lead to acute or chronic anemia due to haemorrhage and / or iron deficiency anemia (e.g. from latent microbleeding) with appropriate laboratory and clinical signs such as asthenia, pallor, hypoperfusion.
4. Necrosis of the nipple and interstitial nephritis have rarely occurred after long-term use of high doses of acetylsalicylic acid. Hypersensitivity reactions with relevant laboratory and clinical signs including: asthma, skin reactions, rash, urticaria, edema, pruritus, cardio-respiratory disorders.
5. Very rarely, severe reactions including anaphylactic shock, hypoglycaemia. Long-term use of medications containing acetylsalicylic acid may cause a headache, which worsens with subsequent doses. Long-term use of painkillers, especially those containing several active substances, can lead to severe renal impairment and kidney failure.