Bactrim with antibacterial effect. How to use?

Bactrim is an antibiotic that has antibacterial properties and is used to treat internal diseases. The drug is prescribed by prescription mainly by general practitioners.

Bactrim, Producer: Roche

Indications for the use of Bactrim

The active substances in Bactrim are sulfamethoxazole, an organic chemical compound that is a bacteriostatic antibiotic, and trimethoprim — chemotherapeutic. Bactrim is best taken after a meal with sufficient fluid. The drug is used for treatment:

1. infections caused by microorganisms sensitive to co-trimoxazole: exacerbation of chronic bronchitis, otitis media;
2. urinary tract infections and soft (venereal) ulcer;
3. gastrointestinal infection, including typhoid fever and travelers’ diarrhea;
4. pneumonia caused by Pneumocystis jiroveci (formerly P. carinii) in adults and children.

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Bactrim – dosage:

1. Adults and children over 12 years of age with normal kidney function:

preparation in the form of tablets: 800 mg of sulfamethoxazole + 160 mg of trimethoprim every 12 hours; in cases of severe infections, the dose may be increased to 1200 mg sulfamethoxazole + 240 mg trimethoprim every 12 hours. The minimum dose for long-term treatment, i.e. more than 14 days, is 400 mg sulfamethoxazole + 80 mg trimethoprim every 12 hours. In the case of acute infections, the preparation should be used for at least 5 days or until there are no symptoms of infection for 2 days. If there is no improvement after 7 days of treatment, a doctor should be consulted.

preparation in the form of a syrup: 4 measuring teaspoons (20 ml) every 12 hours; in cases of severe infections, the dose may be increased to 6 measuring spoons (30 ml) every 12 hours. The minimum dose for long-term treatment (longer than 14 days) is 2 measuring spoons (10 ml) every 12 hours. In the case of acute infections, the preparation should be used for at least 5 days, or until there are no symptoms of infection for at least 2 days. If there is no improvement after 7 days of treatment, a doctor should be consulted.

1. Children under 12 years of age (only the syrup formulation): on average 30 mg / kg body weight / day of sulfamethoxazole + 6 mg / kg body weight / day of trimethoprim in 2 divided doses; recommended dose for children 6 weeks-5. month of life: 1 measuring spoon (2,5 ml) every 12 hours; for children 6 months-5. From the age of 1, 5 measuring spoon (12 ml) every 6 hours; for children 12-2. 10 measuring spoons (12 ml) every XNUMX hours.

Bactrim – use in selected indications:

1. Treatment of a soft ulcer: it is recommended to use Bactrim in the form of tablets. 800 mg of sulfamethoxazole + 160 mg of trimethoprim (2 tablets of Bactrim preparation or 1 table of Bactrim forte preparation) 2 times a day. If there is a need to use the preparation in the form of a syrup, it is recommended to: 4 measuring teaspoons every 12 hours. If there is no improvement after 7 days of treatment, a doctor should be consulted.
2. Single dose treatment in uncomplicated acute urinary tract inflammation in women: it is recommended to use the preparation in the form of tablets. 1600-2400 mg of sulfamethoxazole + 320-480 mg of trimethoprim (4-6 Bactrim prep tablets or 2-3 Bactrim forte prep tablets) once. If there is a need to use the preparation in the form of a syrup, it is recommended to: 8-12 measuring teaspoons every 12 hours. Preferably in the evening, after dinner or at bedtime.
3. Dosage in people undergoing hemodialysis: Regardless of the form of the drug (tablets or syrup), after taking your usual loading doses, take 24 or 48/1 of the initial dose as maintenance doses every 1-3 hours.
4. Pneumonia caused by Pneumocystis jiroveci (formerly P. carinii): maximum dose of 100 mg / kg body weight daily of sulfamethoxazole and 20 mg / kg body weight daily of trimethoprim in 4 divided doses taken every 6 hours for 14 days. The dose will be determined by the doctor in each case (depending on the body weight and form of the preparation).
5. Pneumonia prophylaxis caused by Pneumocystis jiroveci (formerly P. carinii): the recommended dose of Bactrim for adults and adolescents is 800 mg of sulfamethoxazole + 160 mg of trimethoprim (2 tablets of Bactrim preparation or 1 table of Bactrim forte preparation) or 4 teaspoons, i.e. 20 ml of syrup once a day. In children, the recommended dose is 1 mg / m750 of body surface area / day of sulfamethoxazole + 2 mg / m150 of body surface area per day of trimethoprim in 2 divided doses on 2 consecutive days a week. The maximum dose is 3 mg of sulfamethoxazole + 1600 mg of trimethoprim daily.
6. In people with renal insufficiency, the doctor will prescribe the appropriate dosage adjustment. If the creatinine clearance is greater than 30 ml / min, no dose adjustment is needed. If the creatinine clearance is in the range of 15-30 ml / min, the standard dose should be halved. If the creatinine clearance is less than 15 ml / min, the preparation is not recommended.

If you have noticed a reduced frequency of urination, pain while urinating or even a fever, it is worth doing a laboratory diagnosis of kidney disease to find out the cause of the disturbing symptoms.

Contraindications to the use of Bactrim

Contraindication to the use of Bactrim are: hypersensitivity to any component of the preparation or to sulfonamides, severe renal failure (when the drug concentration in the blood cannot be monitored), significant damage to the liver parenchyma, use of dofetilide. Bactrim should not be used in children under 6 weeks of age.

Bactrim and possible side effects

They may appear: body temperature increased, angioedema, anaphylactic shock, very rarely interstitial pneumonia, skin reactions, nausea, vomiting, epigastric pain, diarrhea, pseudomembranous colitis, pancreatitis (especially in immunocompromised patients), hepatitis and biliary tract inflammation, haematological disorders, renal dysfunction, rarely aseptic meningitis or pseudo-meningitis, convulsions, dizziness, tremors, uveitis, rarely joint and muscle pain, increased potassium levels, decreased blood glucose levels.