Azitrox for bacterial infections. How to dose Azitrox?

Azitrox is an antibacterial for general use. Macrolide antibiotic taken to treat bacterial infections caused by microorganisms sensitive to azithromycin. Azitrox is also recommended in upper respiratory tract infection or pharyngitis and sinusitis. The drug in the form of film-coated tablets is available on prescription.

Azitrox, Producer: Zentiva

Indications for taking Azitrox

Treatment of the following infections caused by azithromycin-sensitive microorganisms:

1. upper respiratory tract infections: inflammation of the tonsils, throat, sinuses, acute otitis media,
2. lower respiratory tract infections: bacterial bronchitis, exacerbation of chronic bronchitis, mild to moderately severe interstitial and vesicular pneumonia,
3. skin and soft tissue infections: erysipelas, impetigo, secondarily infected pyoderma; migratory erythema (the first symptom of Lyme disease),
4. sexually transmitted diseases: uncomplicated inflammation of the urethra and cervix caused by chlamydia.

Azitrox and contraindications

A contraindication to taking Azitrox is hypersensitivity to any of the ingredients or other macrolide antibiotics.

Dosage Azitrox

Adults and children weighing more than 45 kg:

– respiratory tract infections, skin and soft tissue infections: 500 mg once a day for 1 days,

– migratory erythema: a single dose of 1 g on the first day, then from the 2nd – 5th day. 500 mg once a day,

– sexually transmitted diseases: 1 g at a time.

Dosage adjustment is not necessary in the elderly.

Children weighing less than 45 kg who can swallow a tablet:

– respiratory tract infections, skin and soft tissue infections: 10 mg / kg body weight once a day for 1 days,

– migratory erythema: on the first day a single dose of 20 mg / kg body weight, then from the 2nd – 5th day. 10 mg / kg body weight once a day.

1. In case of mild to moderate renal impairment (creatinine clearance greater than 40 ml / min), no dosage adjustment of Azitrox is required. There are no data on the use of the preparation in people with a creatinine clearance lower than 40 ml / min and in such cases caution is recommended.
2. Dosage adjustment is not necessary in the presence of mild to moderate hepatic impairment. Do not use in patients with severe liver failure.

Method of administration of Azitrox:

Azitrox is for oral use. The tablets should be taken once a day, swallowed whole, at least 1 hour before or 1 hours after a meal.

Azitrox – warnings

1. Azitrox should be used with caution in patients with neurological or mental disorders.
2. Azitrox should not be used to treat infected burn wounds.
3. If diarrhea occurs during or after treatment with the preparation, do not treat it yourself, but see a doctor immediately. There is a risk of pseudomembranous enteritis, sometimes severe, life-threatening.
4. There is no information on the effect of the preparation on the ability to drive and use machines.
5. The use of antibiotics can cause the overgrowth of resistant bacteria and fungi.
6. A doctor should be consulted immediately if new bacterial or fungal infections appear during the period of application of the preparation (e.g. yeast infections).
7. Pregnant women may use the preparation only if the doctor deems it necessary.
8. It is recommended not to breastfeed while taking Azitroxi for 2 days after discontinuing its use.

Azitrox with other medications

Tell your doctor if you are taking:

1. drugs that can prolong the QT interval on the ECG (including class IA antiarrhythmic drugs, e.g. disopyramide and class III drugs, e.g. amiodarone),
2. terfenadyny,
3. cyzapryd,
4. antacids,
5. ergotamine derivatives (ergot derivatives),
6. digoxin
7. cyclosporins,
8. nelfinawir,
9. anticoagulants (coumarin derivatives, e.g. warfarin),
10. teofiliny,
11. ryfabutyny,
12. astemizole, triazolam, midazolam and alfentanil.

Azitrox – side effects

Azitrox may cause, among other things: diarrhea, abdominal pain, flatulence, digestive disorders, anorexia, constipation, glossitis, pseudomembranous enteritis (manifested by diarrhea), increased liver enzymes or increased bilirubin, rarely liver dysfunction (hepatitis, cholestatic jaundice, liver necrosis and liver failure) liver, rarely fatal), pancreatitis (rare), headache, dizziness, sleepiness, insomnia, seizures, changes in taste, sense of smell, hearing, visual disturbances, loss of consciousness, increased mobility, nervousness, fatigue and weakness (asthenia), Tingling and numbness (paraesthesia), aggressive behavior, restlessness, anxiety, chest pain, palpitations, arrhythmias, risk of ECG QT prolongation and torsade de pointes, hypotension, very rarely interstitial nephritis , acute renal failure.