Aulin with an analgesic effect. Composition, dosage, indications and contraindications

Proven content

Aulin is a preparation from the group of non-steroidal anti-inflammatory drugs. First of all, it has an analgesic and antipyretic effect. The indication for the use of Aulin is the treatment of acute pain as well as primary dysmenorrhea. What are the contraindications to the use of Aulin? Can its use cause side effects in the patient? How much does Aulin cost?

Aulin – general characteristics of the drug

Aulin is a non-steroidal anti-inflammatory drug that is used to treat acute pain. It is also used as an antipyretic drug. This drug is intended for use in various types of pain of various etiology and intensity. The active substance in Aulin is nimesulide.

Aulin is available only on prescription, therefore it has been excluded from mail-order sales and can only be sold in stationary pharmacies.

You can buy Aulin as tablets or granules to be made up into an oral suspension:

1. the drug Aulin in tablets – appear as white to pale yellow, round tablets. The tablets are packed in PVC / Aluminum blisters. Blisters are packed in a cardboard box containing 6, 15 or 30 tablets. Not all pack sizes may be marketed;
2. lek Aulin w granulacie – it is a yellow granular powder for oral suspension. It is packed in 2 g multilayer sachets made of: Paper / Aluminum / LDPE / Surlyn or sachets made of: Aluminum / Paper / LDPE. There are 6, 9, 15 or 30 sachets in a cardboard box. Not all pack sizes may be marketed.

The entity responsible for the production and distribution of Aulin is Angelini Pharma Česká republika sro Angelini Pharma is the pharmaceutical division of Angelini Industries. The group was established almost 100 years ago as a small pharmaceutical laboratory, and over the years it has developed into an international group present in the pharmaceutical industry and the mass market. Angelini Pharma is a healthcare leader, especially in the areas of the central nervous system (CNS) and mental health, including pain and rare disease treatments. Angelini Pharma products are sold in approximately 70 countries. The company operates directly in 25 countries.

What is pain and how to deal with it effectively? Check: Pain – types, mechanism of action, treatment

Aulin – composition and action of the drug

The active substance of Aulin, which has an analgesic and antipyretic effect, is nimesulide. One tablet contains 100 mg of active ingredient. One sachet also contains 100 mg of nimesulide.

Nimesulide is a non-steroidal anti-inflammatory drug belonging to the sulfoanilides. Drugs containing nimesulide have been available for sale since 1985. It is worth mentioning, however, that the use of nimesulide is currently limited as there is a risk of liver damage when taking it. There are only a few preparations available on the Polish pharmaceutical market, the active substance of which is nimesulide.

Nimesulide, like other NSAIDs, has anti-inflammatory, analgesic and antipyretic properties.

It works by inhibiting the activity of cyclooxygenase, an enzyme involved in the synthesis of prostaglandins from lipids in cell membranes. There are at least 2 isoforms of this enzyme COX-1 and COX-2. NSAIDs differ in the specificity of their action against these two isoforms of cyclooxygenase. Classic NSAIDs are active against both COX-1 and COX-2 isoforms. It should be emphasized, however, that nimesulide has a preferential effect over COX-2, and its effect on COX-1 is significantly smaller.

The COX-2 preference promotes the inhibition of prostaglandin synthesis selectively in inflammatory tissues. The inhibition of COX-2 activity underlies the analgesic and anti-inflammatory effects of nimesulide. In addition, nimesulide comprehensively inhibits the action of other inflammatory mediators.

The analgesic effectiveness of nimesulide can be compared to naproxen, diclofenac or ibuprofen.

Nimesulide is well and quickly absorbed from the gastrointestinal tract. It is characterized by a very fast analgesic effect, the onset of which occurs as early as 15 minutes after oral administration of the drug. The maximum concentration in the blood is obtained within 2-3 hours after administration of the preparation.

Due to the safety profile, its use is limited to second-line treatment.

The composition of Aulin also includes auxiliary substances. In the case of Aulin tablets these are sodium docusate, hydroxypropyl cellulose, lactose monohydrate, sodium carboxymethyl starch (type A), microcrystalline cellulose, hydrogenated vegetable oil and magnesium stearate.

Aulin granules in the composition contains such ingredients as: sucrose, maize starch, spray-dried liquid glucose, macrogol cetostearyl ether, anhydrous citric acid and orange flavor.

What are anti-inflammatory drugs and when and how to use them? Check: Anti-inflammatory drugs – types, action, indications and side effects

Aulin – indications for use

Aulin is primarily a drug with analgesic, anti-inflammatory and antipyretic properties. Treatment with this preparation may be initiated in children over 12 years of age and in adults in cases of:

1. acute pain;
2. symptomatic pain in the course of osteoarthritis;
3. dysmenorrhea.

However, it should be remembered that Aulin is a second-line drug. In each case, the doctor will assess the overall risk associated with the use of nimesulide individually and decide on the use of the preparation.

What are the causes of painful periods? Read on: Painful menstruation

Aulin – contraindications to use

The drug Aulin, despite its effectiveness in the treatment of pain, cannot be used by every patient struggling with this type of ailments.

Contraindications to the use of Aulin are:

1. allergy to nimesulide or any of the ingredients of the preparation;
2. having a hypersensitivity reaction or bleeding in the stomach or intestines after taking another non-steroidal anti-inflammatory drug (NSAID);
3. liver damage;
4. active or recurrent peptic ulcer disease;
5. severe blood coagulation disorders;
6. severe heart failure;
7. alcohol addiction;
8. fever and flu-like symptoms;
9. taking other medications that have been known to be toxic to the liver;
10. taking drugs that cause addiction;
11. if you have had liver problems after taking nimesulide in the past;
12. you have severe kidney failure, especially when you have not been on dialysis;
13. have severe heart failure;
14. pregnancy – applies to women in the last 3 months of pregnancy;
15. breast-feeding.

What should you know about drug hypersensitivity? Check: Drugs are also allergenic

Aulin – precautions

Before and during the use of Aulin, follow the precautions included in the package leaflet.

Precautions to keep in mind include:

1. if you develop symptoms that suggest liver problems during treatment with nimesulide, stop taking nimesulide and contact your doctor immediately. Symptoms of liver problems include loss of appetite, nausea, vomiting, abdominal pain, persistent tiredness or dark urine;
2. if you have ever had peptic ulcers, gastrointestinal bleeding, inflammatory bowel conditions such as ulcerative colitis or Crohn’s disease, please inform your doctor before taking Aulin;
3. If during treatment with Aulin you develop fever and / or flu-like symptoms (general muscle pain, malaise, chills), stop taking the medicine and tell your doctor.
4. if you suffer from mild heart disease, high blood pressure, circulation or kidney problems, tell your doctor before taking Aulin;
5. while treating elderly patients, periodic visits may be necessary to make sure that Aulin does not worsen the condition of the stomach, kidneys, heart or liver;
6. if you are planning to become pregnant, tell your doctor as Aulin may reduce fertility;
7. if you have been diagnosed with an intolerance to some sugars, you should contact your doctor before taking the drug.

It’s also worth remembering that taking medications like Aulin may be associated with a slightly increased risk of a heart attack or stroke. This risk is increased by long-term ingestion of high doses of the drug. Therefore, the recommended dose and duration of treatment should not be exceeded. If the patient has heart problems, has had a stroke or is suspected to be at risk of these disorders, the treatment should be discussed with the doctor or pharmacist.

How to deal with pain without medication? Check: Five natural remedies for pain. You don’t have to take the pills

Aulin – dosage and method of application

Always use Aulin exactly as described in the package leaflet or as directed by your doctor or pharmacist.

For Aulin tablets, the usual dose is one tablet (100 mg) twice a day, preferably after meals. Aulin should be used for as short a time as possible, not longer than 15 days in a single, uninterrupted treatment cycle.

However, for Aulin granules, the usual dose is one sachet (100 mg) twice a day, preferably after meals. The contents of the sachet should be dissolved in a glass of water.

How to take medication correctly? Check: How to take medications effectively?

Aulin – improper use of the drug

Taking more than the recommended dose of Aulin or omitting the indicated dose during the day is considered inappropriate use of Aulin.

In the case of overdose or suspected overdose of Aulin contact your doctor or hospital immediately. Take any remaining medications with you. In case of overdose the following symptoms may occur: drowsiness, nausea, abdominal pain, stomach bleeding or difficulty breathing.

Do not use a double dose to make up for a forgotten dose.

Besides medication, what can help you with pain relief? Read: Not only pills – six proven ways to relieve pain

Aulin – side effects

The drug Aulin, like any other drug, may cause side effects in patients. It is important to report any suspected adverse reactions after authorization of the medicinal product so that the benefit / risk balance of the medicinal product can be monitored.

The frequency classification of adverse body reactions (ADRs) is based on the following principles: very common (≥1 / 10), common (≥1 / 100 to <1/10), uncommon (≥1 / 1 to <000/1), rare (≥ 100 / 1 to <10 / 000), very rare (<1 / 1), not known (cannot be estimated from the available data).

Stop taking Aulin immediately and contact your doctor immediately if you experience any of the following side effects:

1. indigestion, stomach pain, nausea, vomiting, bleeding in the stomach or intestine, black stools;
2. skin rash or redness;
3. shortness of breath or wheezing;
4. yellowing of the skin or whites of the eyes;
5. unexpected changes in the color of urine;
6. swelling of the face, feet or legs;
7. persistent feeling of tiredness

The remaining side effects of Aulin can be classified according to their frequency.

Common side effects (may affect more than 1 in 100 patients):

1. diarrhea;
2. nausea;
3. vomiting;
4. slight changes in liver enzymes.

Uncommon side effects (may affect up to 1 in 100 patients):

1. dizziness;
2. high blood pressure;
3. itching and rash;
4. gastric problems (constipation, gas, gastritis);
5. sweating;
6. edema;
7. gastrointestinal bleeding.

Rare side effects (may affect up to 1 in 1000 patients):

1. anemia and other blood count abnormalities;
2. changes in blood pressure;
3. painful urination and urinary retention;
4. hematuria;
5. feeling anxious, anxious and having nightmares;
6. hot flushes;
7. blurred vision;
8. fast heartbeat.

Very rare side effects (may affect up to 1 in 10000 patients):

1. severe skin reactions;
2. bronchospasm;
3. brain dysfunction;
4. hepatitis;
5. kidney failure;
6. bleeding under the skin or elsewhere in the body;
7. black stools;
8. allergies;
9. headache, dizziness;
10. somnolence;
11. lowering body temperature;
12. stomach pain;
13. indigestion;
14. inflammation of the oral mucosa;
15. rash;
16. swelling of the face and surrounding area;
17. blurred vision.

What should you know about pain medications? Check: Everything you need to know about pain medications. Checking!

Aulin – interactions with other drugs

Before starting treatment with Aulin, please inform your doctor or pharmacist about all the medicines you are taking or have taken recently. You should also inform what medications the patient plans to take in the near future.

It is not recommended to combine Aulin with:

1. other non-steroidal anti-inflammatory drugs, including acetylsalicylic acid;
2. cortykosteroidami;
3. anticoagulants, e.g., warfarin;
4. antihypertensive drugs or diuretics;
5. anti-aggregation drugs;
6. antidepressants – lithium and the so-called selective serotonin reuptake inhibitors;
7. methotrexate;
8. cyclosporin.

Which drugs should never be combined with each other? Check: Dangerous interactions

Aulin and pregnancy and breastfeeding

The use of any medications or dietary supplements during pregnancy requires consultation with the attending physician. If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking Aulin.

Aulin must not be used during the last 3 months of pregnancy, as it may expose the fetus to harm and make it difficult to give birth by inhibiting uterine contractions. Additionally, in the first or second trimester of pregnancy, do not exceed the dose and duration of treatment prescribed by your doctor. The doctor individually assesses the risk of using the drug during pregnancy.

Aulin is contraindicated in breast-feeding women, although it is not known whether it passes into breast milk.

What is worth knowing about proper supplementation during pregnancy? Check: Conscious choices. Diet and supplementation in pregnancy

Aulin — cena

Cena leku Aulin may differ depending on the city in which the preparation will be purchased or the pharmacy chosen by the patient. The price of the product also depends on the selected form of the drug and the number of tablets or sachets contained in the package:

1. 30 Aulin tablets cost about PLN 15, after reimbursement – about PLN 12;
2. 15 Aulin tablets cost about PLN 7, after reimbursement – about PLN 6;
3. 30 Aulin sachets cost about PLN 17, after reimbursement – about PLN 8. 

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