Aspirin-C (Aspirin C) – action, indications, contraindications, precautions

Proven content

Aspirin C has an analgesic, anti-inflammatory and antipyretic effect, and thanks to the vitamin C content, it supports the body during the fight against colds or other conditions when the need for vitamin C increases. Aspirin C is a drug used in the symptomatic treatment of headache, muscle pain and tooth aches. The drug relieves the symptoms of colds and flu.

Aspirin C – indications

The indication for the use of Aspirin C is:

1. treatment of low and / or moderate pain, e.g. headache, toothache or muscle pain;
2. treating the symptoms of pain and fever during colds and flu.

Aspirin C – action

W the composition of the drug Aspirin C. there is acetylsalicylic acid with analgesic, anti-inflammatory and antipyretic properties. In addition, the composition also includes vitamin C, which has a beneficial effect on the body during various colds, when there is an increased need for vitamin C.

Acetylsalicylic acid belongs to the group of non-steroidal anti-inflammatory drugs, the so-called NSAIDs. The mechanism of its action is therefore based on the inhibition of the activity of cyclooxygenases, i.e. enzymes involved in the synthesis of prostaglandins and thromboxane from lipids in cell membranes. The inhibition of prostaglandin synthesis is the basis of the analgesic and anti-inflammatory properties of acetylsalicylic acid, while the inhibition of thromboxane synthesis is the basis of the anti-aggregation effect.

Acetylsalicylic acid is absorbed from the gastrointestinal tract and the rate of absorption depends on the form of the drug. Therefore, Aspirin C is in the form of effervescent tablets, which significantly accelerates the absorption of active substances.

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Aspirin C – composition

W 1 Aspirin C tablet is located:

1. 400 mg of acetylsalicylic acid;
2. 240 mg of ascorbic acid.

Additionally, one effervescent tablet also contains 933 mg of sodium.

Aspirin C – contraindications

Even if they exist indications for use of Aspirin C. it is not always possible to administer the drug. The contraindication to use is:

1. hypersensitivity to active substances or excipients Aspirin C.;
2. hemorrhagic diathesis;
3. acute gastric or duodenal ulcer;
4. bronchial asthma attacks induced by the administration of salicylates or substances with a similar effect, especially drugs from the NSAID group;
5. severe heart failure, severe liver failure, or severe kidney failure;
6. simultaneous use of methotrexate in doses of 15 mg per week or more;
7. third trimester of pregnancy;
8. age – does not apply Aspirin C in children under 12 years of age.

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Aspirin C – side effects

Side effects resulting from the use of Aspirin C include:

1. gastrointestinal disorders – stomach and abdominal pain, nausea, vomiting, heartburn, indigestion, gastrointestinal inflammation, life-threatening gastrointestinal bleeding (these can be evident, e.g. tarry stools or occult), stomach ulcer or duodenum or perforation;
2. hepatobiliary disorders – occasional cases of transient liver disorders have been reported;
3. nervous system disorders – dizziness and tinnitus, which most often may indicate an overdose;
4. blood and lymphatic system disorders – higher risk of bleeding, hematomas, prolonged bleeding time, prothrombin time, haemorrhages, e.g. from the nose, after operations, thrombocytopenia. Bleeding may lead to acute or chronic iron deficiency anemia or acute haemorrhagic anemia (symptoms include asthenia, pallor, hypoperfusion, and abnormal blood test results). In patients with severe forms of glucose-6-phosphate dehydrogenase deficiency, haemolysis and haemolytic anemia may occur;
5. vascular disorders – cerebral hemorrhage, especially in people with blood pressure disorders that can be life-threatening;
6. disorders of the kidneys and urinary tract – also severe renal failure;
7. disorders of the immune system – hypersensitivity reactions with clinical symptoms and abnormal laboratory test results. These are most often: asthma, skin reactions, respiratory and cardiovascular disorders. These include rash, hives, swelling, breathing problems, heart problems, rhinitis, nasal congestion, but also severe reactions such as anaphylactic shock;
8. respiratory system disorders – bronchial asthma;
9. headache – headache may occur as a result of long-term use of acetylsalicylic acid, especially when taking subsequent ones Aspirin C doses.

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Aspirin C – dosage

The dosage of Aspirin C is as follows:

1. adults – 1-2 effervescent tablets at a time, i.e. 400-800 mg of acetylsalicylic acid and 240-480 mg of ascorbic acid. A single dose can be repeated every 4-8 hours as needed. However, remember not to take more than 8 tablets during the day;
2. adolescents over 12 years of age – Aspirin C can be given to adolescents over 12 years of age only on the express recommendation of a doctor. A single dose is then 1 effervescent tablet, i.e. 400 mg of acetylsalicylic acid and 240 mg of ascorbic acid. The dose can be taken again every 4-8 hours if needed. However, remember not to exceed the daily dose of 3 tablets.

Aspirin C should not be used by children. The drug should not be taken without consulting a doctor for more than 3-5 days. Aspirin C tablets it is administered only orally. The tablets should be dissolved and the effervescent liquid should be drunk.

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Aspirin C – precautions

Caution when using Aspirin C. should be kept in the case of:

1. hypersensitivity to NSAIDs, anti-rheumatic drugs or other substances that may cause allergenic substances;
2. simultaneous use of anticoagulants;
3. impaired liver function;
4. impaired renal function or circulatory disorders, such as congestive heart failure, major surgery, sepsis, as acetylsalicylic acid may aggravate the occurrence of renal disorders and severe renal failure;
5. history of peptic ulcer disease (chronic or recurrent) and gastrointestinal bleeding;
6. glucose-6-phosphate dehydrogenase deficiency because acetylsalicylic acid contained in Aspirin C. may lead to the development of haemolysis or haemolytic anemia. The risk of haemolysis is influenced by high doses of acetylsalicylic acid, high body temperature, severe infections and, for example, breastfeeding.

Acetylsalicylic acid has anti-aggregating properties for up to several days after administration, therefore it may extend the bleeding time during and after surgery, also after tooth extraction. In low doses, it reduces the excretion of uric acid, which can trigger gout in people at risk.

Administration of Aspirin C during certain viral diseases (especially influenza A, type B and chickenpox infections) may lead to the development of Reye’s syndrome – a serious, life-threatening disease. This is especially true of children. Therefore, it is not recommended to administer Aspirin C to children under 12 years of age, and adolescents over 12 years of age may take the drug on the express recommendation of a doctor.

Long-term use of Aspirin C. it may cause headaches, which worsen with subsequent doses. In addition, long-term use of painkillers may lead to severe renal dysfunction and renal failure. Drugs that inhibit cyclo-oxygenase can also lead to transient fertility problems in women as they affect ovulation. However, this is a temporary effect.

People with calcium oxalate nephrolithiasis or recurrent nephrolithiasis should also be especially careful. People controlling the amount of sodium in the diet should also bear in mind that one effervescent tablet contains as much as 933 mg of sodium.

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Aspirin C – pregnancy

Before using Aspirin C. please consult your doctor. The drug inhibits the synthesis of prostaglandins, which may adversely affect the pregnancy and / or the development of the embryo or fetus. They also increase the risk of miscarriage, congenital heart defects and congenital gastroschisis, and the overall risk of congenital cardiovascular defects increases from 1%. up to 1,5 percent The risk is assumed to increase with dose and duration of treatment.

Therefore, drugs containing acetylsalicylic acid are not recommended for women in the first and second trimesters of pregnancy, unless absolutely necessary. In case of emergency taking Aspirin C. by women trying to conceive and women in the first and second trimesters, the lowest effective dose should be taken for the shortest possible time.

In turn, in the third trimester of Aspirin C, like all prostaglandin synthesis inhibitors, they can:

1. have a toxic effect on the circulatory system and the respiratory system of the fetus – they may even lead to premature closure of the arterial duct and pulmonary hypertension;
2. interfere with kidney function and lead to renal failure and oligohydramnios.

However, at the end of pregnancy, both the woman and the newborn are exposed to:

1. prolongation of bleeding and anti-aggregation effect – may occur even after administration of low doses;
2. inhibition of uterine contractions and thus delayed or prolonged labor.

Therefore, Aspirin C is contraindicated in the third trimester of pregnancy.

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Aspirin C – breastfeeding

Acetylsalicylic acid contained in Aspirin C. and its metabolites may pass into breast milk in small amounts. To date, no adverse effects have been reported in breastfed infants, whose mothers used salicylates for a short time. Therefore, as a rule it is not necessary to stop feeding. This is only recommended when high doses are used over a long period of time.

Aspirin C – fertility

Scientific evidence shows that drugs that inhibit cyclo-oxygenase, i.e. prostaglandin synthesis, can impair female fertility because they affect ovulation. However, it should be remembered that this is a temporary effect and disappears after the end of the preparation.

Aspirin C – taking other preparations

Before administering Aspirin C, inform your doctor about all medications you are taking, including those without a prescription. It is contraindicated:

1. simultaneous use of acetylsalicylic acid and methotrexate in doses of 15 mg per week or more, as this may increase the toxic effect of methotrexate on the bone marrow and cause severe life-threatening poisoning. In this case, it is necessary to consult a doctor beforehand and change the dosage or stop using one of the preparations;
2. use of anticoagulants, such as warfarin or heparin – higher risk of bleeding;
3. the use of selective serotonin reuptake inhibitors, such as citalopram – higher risk of bleeding;
4. the use of ibuprofen – the risk of reducing the anti-aggregating effect of acetylsalicylic acid;
5. use of other NSAIDs – higher risk of side effects;
6. taking drugs that increase the excretion of uric acid in the urine, such as probenecid – the risk of reducing the effect of these drugs and a gout attack;
7. the use of cardiac glycosides, such as digoxin – the possibility of increasing its effect;
8. use of anti-diabetic drugs, such as insulin – intensification of their effect, high risk of hypoglycaemia,
9. the use of thrombolytic drugs, such as alteplase and drugs that inhibit platelet aggregation, such as clopidogrel – increased effect, prolonged bleeding and high risk of haemorrhage;
10. taking diuretics, e.g. furosemide – the risk of lower effectiveness of the drug and its toxic effect on the hearing organ;
11. taking antihypertensive drugs (angiotensin converting enzyme inhibitors, angiotensin antagonists and beta-blockers) – lower antihypertensive effect;
12. Systemic use of glucocorticosteroids (except hydrocortisone in Addison’s disease) – higher risk of peptic ulcer and / or duodenal disease, as well as gastrointestinal bleeding;
13. taking valproic acid – the risk of higher toxicity and a strong anti-aggregation effect.

We should also remember that alcohol consumption increases the risk of side effects related to the gastrointestinal tract, including hemorrhages. In addition, vitamin C can interfere with laboratory test results.

Before use, read the leaflet, which contains indications, contraindications, data on side effects and dosage as well as information on the use of the medicinal product, or consult your doctor or pharmacist, as each drug used improperly is a threat to your life or health. Do you need a medical consultation or an e-prescription? Go to halodoctor.pl, where you will get online help – quickly, safely and without leaving your home. Now you can use e-consultation also free of charge under the National Health Fund.