Aspirin Activ – action, indication, dosage, side effects

The drug is used for pain of low and moderate intensity (headaches, muscle aches, etc.).

Active Aspirin (Bayer).

SUBSTANCE 1 tablet contains: 0,5 g of acetylsalicylic acid, 0,05 g of caffeine.

ACTION

Combined preparation with analgesic, antipyretic and anti-inflammatory properties.

INDICATIONS AND DOSAGE

Pain of mild and moderate intensity (headache, muscle aches, etc.). Use orally, do not take on an empty stomach. Adults. 1-2 tablets once. If necessary, the dose can be repeated every 6-8 h, up to a maximum of 6 tablets / day.

CONTRAINDICATIONS

Hypersensitivity to salicylates, caffeine, gastric or duodenal ulcer disease, haemorrhagic diathesis, severe heart, liver or kidney failure, severe cardiovascular disease or severe hypertension, history of bronchial asthma attacks, caused by salicylates or other non-steroidal anti-inflammatory drugs, parallel use of methotrexate in doses> = 15 mg / week, pregnancy, breastfeeding. Do not use in children up to 12 years of age, especially in the course of viral infections.

WARNINGS

If symptoms worsen or do not improve after 3 days, please contact your doctor. Particular care should be taken in the case of hypersensitivity to non-steroidal anti-inflammatory drugs or other allergenic substances, liver or kidney dysfunction, hyperthyroidism, gastric and / or duodenal ulcer disease or history of gastrointestinal bleeding, glucose-6-phosphate dehydrogenase deficiency and during concomitant use. use of anticoagulants (e.g. coumarin derivatives, heparin). Acetylsalicylic acid may cause bronchospasm and trigger asthma attacks or other hypersensitivity reactions. Patients with bronchial asthma, chronic respiratory diseases, allergic rhinitis (hay fever), nasal polyps and allergic reactions to other substances (e.g. skin reactions, pruritus, urticaria) are particularly at risk of such reactions. Before surgery (including minor procedures, such as tooth extraction), patients should inform their doctor that they are taking the preparation. Acetylsalicylic acid, even in low doses, reduces the excretion of uric acid from the body. In patients prone to decreased uric acid excretion, the drug may cause gout attacks. The drug may adversely affect female fertility; this effect is transient and disappears after discontinuation of therapy.

INTERACTIONS

Acetylsalicylic acid increases the toxicity of methotrexate on the bone marrow (acetylsalicylic acid should not be used simultaneously with methotrexate used in doses of 15 mg per week or more; concomitant use of methotrexate in doses lower than 15 mg per week requires special care), the effect of anticoagulants (e.g. coumarin derivatives, heparin), thrombolytic drugs (dissolving clot, e.g. streptokinase, urokinase) and inhibiting platelet aggregation (clumping) (e.g. ticlopidine), which may increase the risk of prolonged bleeding time and haemorrhage. It increases the risk of ulceration and gastrointestinal bleeding if it is used concomitantly with corticosteroids, other non-steroidal anti-inflammatory drugs (including other high-dose salicylates), or if alcohol is consumed during treatment. After stopping treatment with systemic corticosteroids (with the exception of hydrocortisone used as replacement therapy in Addison’s disease), the risk of salicylate overdose increases. It intensifies the effect of digoxin (increases its concentration in plasma), the effect of antidiabetic drugs (e.g. insulin, sulfonylurea derivatives), the toxic effect of valproic acid (while valproic acid enhances the anti-aggregating effect of acetylsalicylic acid). Acetylsalicylic acid reduces the effect of drugs used to treat gout, which increase the excretion of uric acid from the body (e.g. benzbromarone, probenecid) (this may worsen gout symptoms), diuretics, some antihypertensive drugs (angiotensin converting enzyme inhibitors, e.g. captopril , enalapril). Particular care should be taken when using the preparation with sedatives and hypnotics (e.g. barbituric acid derivatives or antihistamines) because caffeine inhibits their effect, with drugs that may increase the heart rate (caffeine may increase their effect), theophylline (caffeine inhibits its excretion) , oral contraceptives, cimetidine and disulfiram (inhibit caffeine metabolism in the liver), barbituric acid derivatives (accelerate caffeine metabolism), certain antibiotics (can delay the excretion of caffeine and its metabolite). Smoking tobacco accelerates the metabolism of caffeine. Caffeine increases the possibility of addiction to substances with effects similar to ephedrine (contained in heart drugs). The preparation can be used simultaneously with the above-mentioned drugs (except for methotrexate used in doses of 15 mg per week or more) only after consulting a doctor.

SIDE EFFECTS

The following may occur: stomach and abdominal pain, heartburn, nausea, vomiting, indigestion, inflammation of the gastrointestinal tract, potentially life-threatening gastrointestinal bleeding: overt (fuzzy vomiting, tarry stools) or latent (bleeding occurs more often the higher the dose); gastric or duodenal ulcer, perforation. Transient liver dysfunction (elevated transaminases) has been reported in rare cases. Dizziness and tinnitus, usually symptoms of overdose, headache, insomnia, restlessness. Increased risk of bleeding, haemorrhage (postoperative, epistaxis, gingivitis, urogenital), hematomas, prolonged bleeding time, prothrombin time, thrombocytopenia. Bleeding may result in acute or chronic iron deficiency anemia, or acute haemorrhagic anemia, manifested by weakness, pallor, hypoperfusion, and abnormal laboratory test results. Haemorrhagic stroke (especially in patients with uncontrolled hypertension and / or taking other anticoagulants concomitantly) potentially life-threatening. Palpitations, hot flush to the face, uneven heart beat, high blood pressure, increased heart rate. Renal papilla necrosis and interstitial nephritis have been reported in rare cases after long-term use of high doses of acetylsalicylic acid. Hypersensitivity reactions with clinical symptoms and abnormal results of appropriate laboratory tests, such as: bronchial asthma, mild to moderate reactions involving the skin, respiratory system, cardiovascular system with symptoms such as: rash, urticaria, edema (including angioedema), respiratory disorders and heart rate, and very rarely severe reactions including anaphylactic shock. High doses of caffeine may adversely affect the heart, causing palpitations, flushing, high blood pressure, and tachycardia. Long-term use of preparations containing acetylsalicylic acid may cause a headache, which worsens with the use of subsequent doses. Long-term intake of painkillers, especially those containing several active substances, may lead to severe renal impairment and kidney failure. If ground-like vomiting or black tarry stools appear, stop taking the medicine and see your doctor. Symptoms of a severe hypersensitivity reaction may include swelling of the face and eyelids, swelling of the tongue and larynx with narrowing of the airways, difficulty breathing, shortness of breath up to asthma attacks, increased heart rate, sudden fall in blood pressure up to life-threatening shock. If any of these symptoms occur, get medical attention immediately. The above reactions may occur even after the first administration of the drug. Edema, hypertension and cardiac failure have been reported in association with NSAID treatment.