Aprofen for low to moderate pain. Aprofen interactions with other drugs

It is used for pain of various origins of low and moderate intensity (headache, toothache, neuralgia, pain in muscles, joints and bones, pain in the course of colds and flu, menstrual pain) and fever in the course of colds, flu and other infectious diseases.

Aprofen, Aprofen Forte (Polfarmex)

ACTION

Non-steroidal anti-inflammatory drug

INDICATIONS AND DOSAGE

Pain of various origins of low and moderate intensity (headache, toothache, neuralgia, pain in muscles, joints and bones, pain in the course of colds and flu, menstrual pain), fever in the course of colds, flu and other infectious diseases. Adults and children over 12 years of age. Orally with fluid. 200–400 mg once or up to 4 times a day; dose max. 1200 mg / day. The preparation is not recommended for children weighing less than 7 kg. In children who cannot be given the whole tablet, an alternative formulation of ibuprofen is recommended.

CONTRAINDICATIONS

Hypersensitivity to ibuprofen, other non-steroidal anti-inflammatory drugs or any of the ingredients of the preparation, allergy symptoms (runny nose, urticaria, asthma) after taking acetylsalicylic acid or other non-steroidal anti-inflammatory drugs in a history of active or previous gastric or duodenal ulcer disease, perforation or bleeding from the gastrointestinal tract, severe liver, kidney or heart failure, hemorrhagic diathesis, parallel use of other non-steroidal anti-inflammatory drugs, including COX-2 inhibitors, third trimester of pregnancy.

WARNINGS

Particular caution should be exercised in people with arterial hypertension and / or cardiac dysfunction, with impaired liver function, with impaired renal function. Patients with systemic lupus erythematosus and mixed connective tissue disease are at increased risk of developing aseptic meningitis. Patients with a history of gastrointestinal disease such as ulcerative colitis, Crohn’s disease and Crohn’s disease may worsen them. Ibuprofen increases the risk of bronchospasm in people with bronchial asthma or a history of asthma and allergic diseases. The elderly are at increased risk of side effects. To reduce the risk of side effects, it is recommended to take the preparation in the lowest effective dose for the shortest possible period. Non-steroidal anti-inflammatory drugs can cause visual disturbances (scotomas, color vision disturbances); if they occur, treatment should be discontinued and a doctor consulted. There is a risk of gastrointestinal haemorrhage, ulceration or perforation which may be fatal and may not necessarily be followed by warning symptoms. Tell your doctor about any unusual gastrointestinal symptoms (especially bleeding), especially at the beginning of treatment. This applies especially to the elderly and people with gastrointestinal diseases, for whom it is recommended to use the lowest dose possible. The use of anticoagulants (e.g. warfarin, acenocoumarol), anti-aggregation drugs (e.g. acetylsalicylic acid), corticosteroids increase the risk of bleeding and gastrointestinal dysfunction. Caution should be exercised during parallel use with cyclosporine, methotrexate, digoxin, lithium, probenecid, valproic acid. Alcohol consumption increases the risk of gastrointestinal bleeding. Ibuprofen may cause a sudden drop in blood glucose levels. The preparation contains lactose; patients with hereditary disorders of galactose intolerance, the lactase deficiency or malabsorption of glucose-galactose should not use the preparation. Patients with a history of hypertension or mild to moderate congestive heart failure, fluid retention and edema should consult a physician before using the preparation. Fluid retention and edema have been reported in association with treatment with NSAIDs. Long-term use of the preparation in high doses may increase the risk of a heart attack or stroke. Long-term parallel use of ibuprofen and other pain medications may cause renal failure. Severe skin reactions, some of them fatal (exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis), may occur. The greatest risk of the above-mentioned reactions occurs at the beginning of treatment. At the first appearance of skin symptoms (e.g. rash, lesions of the oral mucosa, other signs of hypersensitivity) or nosebleeds, chest pain, seizures, fainting, visual disturbances (scotoma, color vision disturbances) should be discontinued and your doctor consulted. Caution should be exercised in people with bleeding disorders or treated with anticoagulants; bleeding time may be longer. There is evidence that NSAIDs can cause temporary impairment of female fertility. It is not recommended for use in women in the first and second trimester of pregnancy; use in the first and second trimesters of pregnancy only with the consent of the doctor and only if absolutely necessary. Use in the third trimester of pregnancy is contraindicated. Before using the preparation during breastfeeding, consult your doctor. People driving motor vehicles should be careful because in rare cases, mainly with high doses, visual disturbances (blurred or double vision) may occur.

INTERACTIONS

Non-steroidal anti-inflammatory drugs, including ibuprofen, should not be used with the following drugs: acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (as the risk of side effects increases); diuretics or antihypertensives (possible reduction in their effectiveness); anticoagulants (possible increase in their effect, e.g. warfarin); zidovudine (risk of prolonged bleeding); methotrexate and lithium (possible increase in plasma levels of both lithium and methotrexate; it is recommended to control their concentration in the blood); corticosteroids (increased risk of side effects, especially in the gastrointestinal tract); cardiac glycosides (risk of increasing heart failure and increasing the concentration of cardiac glycosides in the plasma); mifepristone (non-steroidal anti-inflammatory drugs used for 8 to 12 days after mifepristone administration may reduce its effectiveness); cyclosporin (increased risk of nephrotoxicity); quinolone antibiotics (increased risk of convulsions). Alcohol consumption increases the risk of gastrointestinal bleeding.

SIDE EFFECTS

The following may occur: indigestion, pain and discomfort in the abdomen, heartburn, nausea, diarrhea, flatulence, constipation, vomiting, gastritis, ulcerative stomatitis, exacerbation of colitis, Crohn’s disease, tarry stools, bloody vomiting, duodenitis, oesophagitis, gastric ulcer and / or duodenal ulcer, gastrointestinal bleeding and perforation (may be fatal, especially in the elderly), liver dysfunction, hepatitis, pancreatitis, jaundice, increased enzyme levels dizziness and headache, depression, insomnia, confusion, mood swings, agitation, drowsiness, irritability and fatigue, seizures, aseptic meningitis with fever or coma, tinnitus, hearing loss, visual disturbances, decreased urine output, renal failure, renal papillary necrosis, increased sodium concentration in os blood eyes (sodium retention), edema, high blood pressure, heart failure. Very rarely, disorders of the blood and the lymphatic system may occur, such as: haemolytic and aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, pancytopenia (the first symptoms of these disorders include: fever, sore throat, superficial ulceration of the oral mucosa, flu-like symptoms, fatigue, bleeding) , bruises, ecchymosis, purpura, epistaxis). Hypersensitivity reactions and allergic reactions (rash, itching of the skin, hives, erythema multiforme, swelling of the face, larynx, tongue, dyspnoea, decreased blood pressure, shock, acute shock, exacerbation of asthma, bronchospasm, Stevens-Johnson syndrome, toxic necrosis) may occur. loose epidermis, alopecia, exfoliative dermatitis, photosensitivity). Isolated cases of symptoms associated with aseptic meningitis (neck stiffness, headache, nausea, vomiting, fever, confusion) have been reported in people with autoimmune diseases (e.g. lupus erythematosus). Long-term use of ibuprofen in high doses (2400 mg daily) may increase the risk of heart attack or stroke.