Apap C Plus for colds and flu. How many Apapu tablets can you take per day?

Apap C Plus is a drug used for the short-term treatment of cold and flu symptoms (fever, headache, sore throat, muscle pain, bone and joint pain). The drug is a combined preparation with analgesic and antipyretic properties. The active substances of the preparation are ascorbic acid and paracetamol. The preparation is in the form of effervescent tablets and is intended for oral administration.

Apap C Plus (US Pharmacia)

SUBSTANCE 1 tablet contains: 0,5 g of paracetamol, 0,3 g of ascorbic acid.

ACTION

Apap C Plus is a combined preparation with analgesic and antipyretic properties.

Apap C Plus – indications and dosage

Apap C Plus are effervescent tablets used in the short-term treatment of cold and flu symptoms:

1. fever,
2. Headache,
3. sore throat,
4. muscle aches,
5. osteoarticular pain.

Drug dosage

Apap C Plus is in the form of effervescent tablets, which should be dissolved in 1/2 glass of water at room temperature. Do not exceed the recommended dose of the preparation as it may pose a threat to your life or health.

1. Adults and children after 12 years of age 1 tablet every 4-6 h, max. 3 tabl./d.

Apap C plus and contraindications

Contraindications to taking Apap C Plus are:

1. allergy to any ingredient of the preparation,
2. congenital deficiency of glucose-6-phosphate dehydrogenase,
3. severe renal or hepatic insufficiency,
4. viral hepatitis,
5. alcoholism,
6. fenyloketonuria,
7. use of MAO inhibitors in parallel or during the last 2 weeks,
8. parallel use of zidovudine,
9. use in children up to the age of 12

Apap C plus – drug restrictions

1. If the symptoms after treatment with the drug do not improve or worsen – consult a doctor.
2. Pregnant and breastfeeding women may take the drug only after consulting a doctor and in case of absolute necessity.
3. Do not exceed the recommended doses of the drug.
4. Check that other taken preparations do not contain paracetamol in order to avoid overdosing.
5. The analgesic effect of the drug is enhanced by the concomitant consumption of caffeine.
6. Patients with hepatic insufficiency, alcohol abusers and starving patients are at risk of liver damage.
7. People with renal and hepatic insufficiency, bronchial asthma, cholelithiasis, haemochromatosis, and those following a low-sodium diet should take Apap C Plus with caution.
8. Do not consume alcohol during treatment with Apap C Plus.

Apap C plus with other drugs

1. Apap C Plus should not be used with other drugs containing paracetamol.
2. Preparations that accelerate gastric emptying accelerate the absorption of paracetamol, while drugs that delay emptying may delay paracetamol absorption.
3. Taking the drug may increase the work of anticoagulants, e.g. warfarin.
4. Concomitant use of Apap C Plus with rifampicin, isoniazid, anti-epileptics (e.g. phenobarbital, phenytoin, carbamazepine), barbiturates, diflunisal, sulfinpyrazone or other drugs inducing liver microsomal enzymes may lead to liver damage.
5. Administration of the drug with MAO inhibitors and within 14 days after the end of treatment with these drugs may cause high temperature and agitation.
6. Paracetamol in combination with zidovudine increases the toxic effect of zidovudine on the bone marrow and may cause liver damage.
7. Consuming caffeine enhances the effects of the drug.
8. Drinking alcohol during treatment with the drug may cause necrosis of liver cells.
9. Ascorbic acid causes increased absorption of aluminum from drugs containing it and increased absorption of iron.
10. Taking the preparation may have an influence on the false results of some laboratory tests (glucose or creatinine determination).

Apap C plus – side effects

Taking Apap C plus may cause the following side effects:

1. nausea,
2. vomiting,
3. digestive disorders,
4. allergic reactions: urticaria, erythema, rash, pigmentary purpura, angioedema, dyspnoea, asthma attack, hypotension, anaphylactic shock,
5. rarely haematological disorders (e.g. thrombocytopenia, granulocytopenia, agranulocytosis),
6. renal colic
7. renal papillary necrosis,
8. acute kidney failure,
9. urolithiasis,
10. acute liver damage (usually from overdose) may rarely occur.