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Antidol 15 is a medicine used in family medicine to treat pain of various origins. The preparation acts on the central nervous system, has analgesic and antipyretic properties. Antidol 15 is available in tablet form and is sold without a prescription.
Antidol – characteristics
| Form, dose, packaging | Availability category | The active substance |
|---|---|---|
| pills; 1 tablet contains: 500 mg of paracetamol and 15 mg of codeine; 10 pieces | over-the-counter drug | codeine, paracetamol |
Antidol – action
Antidol is a pain reliever drug that can be purchased at a pharmacy without a prescription. The drug is available in the form of tablets in packs of 10 pieces. Antidol is not a reimbursed drug.
The composition of Antidol includes two active substances: paracetamol and codeine:
- paracetamol is designed to stop the peripheral transmission of pain by stopping the synthesis of prostaglandins. This substance is also supposed to reduce the fever;
- codeine – has a central effect. It is an analgesic that acts on μ opioid receptors. It is transformed in the same way as morphine and therefore has an analgesic effect.
The combination of these two substances provides more effective the effect of Antidol in the case of acute nociceptive pain. Both act quickly and are easily absorbed from the gastrointestinal tract when swallowed.
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Antidol – composition
Active substances of Antidol is 500 mg of paracetamol and 15 mg of codeine phosphate. In addition, the composition of the drug includes: gelatinized maize starch, stearic acid, povidone and crospovidone.
The composition also includes microcrystalline cellulose, anhydrous colloidal silica and magnesium stearate.
Antidol – indications
Antidol is recommended for adults in case of pain of moderate or high intensity and of various origins. According to the Antidol manufacturer’s leaflet, the drug can be used in the case of:
- pain after tooth extraction;
- headache;
- osteoarticular pain;
- pain in soft tissues;
- menstrual pain.
In the case of children over 12 years of age, it is allowed to use Antidol during the treatment of acute pain of moderate intensity. Its use, however, is justified if other agents with a similar effect did not alleviate the symptoms, i.e. the use of paracetamol or ibuprofen alone.
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Antidol – dosage
Antidol should only be used orally and only when necessary. The drug is administered after a meal and washed down with plenty of water. The dosage is as follows:
- adults and adolescents over 15 years of age should take 1 or 2 tablets up to 4 times a day. Remember to leave a break of at least 6 hours between successive doses. During the day, however, do not take more than 6 tablets during the day;
- adolescents between 12 and 15 years of age can take 1 tablet every 6 hours and a maximum of 4 tablets a day. Remember that the final dose of the drug for this age group should be determined on the basis of the patient’s weight. The dose of Antidol is from 0,5 to 1 mg per 1 kg of body weight, and up to 240 mg of the substance can be taken during the day.
Antidol can be used for a maximum of 3 days. If, after this time, the pain does not decrease or does not subside, consult your doctor. It is very important that the medicine is taken for the shortest possible time at the lowest effective dose.
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Antidol – contraindications
Although Antidol can be purchased without a prescription, it cannot be used in every case and for every patient. Contraindication to its use is:
- simultaneous use of MAO inhibitors and a period of 2 weeks after the end of therapy;
- respiratory failure;
- congenital deficiency of glucose-6-phosphate dehydrogenase and methaemoglobin reductase;
- hemolytic anemia;
- rapid metabolism with the participation of the enzyme CYP2D6;
- the period of breastfeeding;
- children and adolescents under 18 years of age – Antidol should not be used in this age group after the removal of the palatine or pharyngeal tonsil as a treatment for obstructive sleep apnea syndrome. The use of Antidol can cause serious side effects;
- children under 12 years of age – Antidolium can cause serious side effects.
- hypersensitivity to any component of the preparation,
- severe liver or kidney failure,
- alcoholism.
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Antidol – precautions
Restrictions on the use of Antidol apply to minors who can be administered codeine according to strictly defined rules:
- Antidol should not be administered to people aged 12-18 years for the symptomatic treatment of colds who struggle with impaired respiratory function;
- Antidol cannot be administered to people under 12 years of age, which is associated with a high risk of opioid toxicity due to the variable and unpredictable metabolism of codeine to morphine.
In addition, people with severe renal insufficiency should increase the interval between doses of Antidol to 8 hours between doses.
This also applies to people with liver disorders and diagnosed with Gilbert’s syndrome, for whom the dose should be reduced or the time between successive doses should be extended. It also happens that these changes are necessary in the elderly.
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Antidol – side effects
Antidol, like many other over-the-counter medications, can lead to various side effects in patients. During treatment with the drug, the most common reports were:
- headache and dizziness;
- severe fatigue;
- drops in blood pressure;
- nausea;
- constipation;
- vomiting;
- fainting – if you have taken too much Antidol.
In some people, after administering Antidol, there were:
- sleep disturbance;
- skin conditions: rash, hives, itching and reddening of the skin.
Also possible are:
- Tinnitus;
- shortness of breath;
- dry mouth;
- allergic eczema;
- visual disturbances or constriction of the pupils – after taking too high doses.
Very rarely, the use of Antidol resulted in:
- thrombocytopenia;
- leukopenia;
- agranulocytozy;
- pancytopenia (isolated cases);
- hypersensitivity reactions: angioedema, dyspnoea, malaise, sweating, pressure drops, shock;
- bronchospasms;
- toxic epidermal necrolysis;
- Stevens-Johnson syndrome;
- acute generalized pustular eruption;
- increased euphoria or dysphoria – after taking too high doses;
- coordination disorders;
- pulmonary edema;
- respiratory depression.
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Antidol – interaction with alcohol
Antidol should not be combined with alcohol as strong or moderate interactions may occur. Drunken alcohol enhances the adverse effects of paracetamol on the liver. However, the codeine contained in Antidol may increase the depressive effect of alcohol on the central nervous system and respiration.
Alcohol-dependent people, on the other hand, are at risk of fatal liver damage, both with paracetamol in therapeutic doses and with overdose. However, if the maximum daily dose of 4 g of paracetamol is not exceeded, the activity of liver enzymes and INR in this group does not change.
People who have ever abused alcohol should exercise extreme caution.
Antidol – pregnancy and breastfeeding
Antidol should not be used during pregnancy. The drug can only be used if absolutely necessary and on a case-by-case basis. Antidol should also not be administered during labor as it may increase the risk of respiratory depression in the newborn.
It is not known what effect the combination of codeine and paracetamol has on fetal development. Although animal studies have not shown an increased risk to the fetus, the use of the drug in pregnant women is not recommended. There is a risk that codeine will lead to the development of congenital abnormalities in the respiratory system in the fetus.
Under no circumstances should Antidol be taken while breastfeeding. Codeine, paracetamol and the codeine metabolite morphine are excreted in breast milk. Although these are small amounts and should not affect your baby, some women who are CYP2D6 metabolisers, opioids may reach higher blood levels. This can cause symptoms of opioid toxicity in the child, which can even lead to the death of the child.
Before use, read the leaflet, which contains indications, contraindications, data on side effects and dosage as well as information on the use of the medicinal product, or consult your doctor or pharmacist, as each drug used improperly is a threat to your life or health. Do you need a medical consultation or an e-prescription? Go to halodoctor.pl, where you will get online help – quickly, safely and without leaving your home.