Anapran Neo – indications, dosage, interactions with other drugs, side effects

Anapran Neo is a medicine used in family medicine, sports medicine and rheumatology. The preparation affects the musculoskeletal system, eliminating pain of various intensity and origin. Anapran Neo is available in pharmacies over the counter in the form of coated tablets.

Anapran neo (Polfa Pabianice SA)

Indications for use of Anapran Neo

Anapran Neo is used to relieve pain in muscles, joints, teeth and head, and during painful menstruation. The drug has anti-inflammatory properties – it relieves the symptoms of colds and flu. The active ingredient in Anapran Neo is naproxen – a non-steroidal anti-inflammatory drug.

Dosage:

1. Adults and children over 16 years of age: 220 mg every 8-12 hours or a single dose of 440 mg initially, 12 mg after 220 hours, then 220 mg every 12 hours if necessary. The maximum dose of Anapran Neo is 660 mg per day;
2. Patients over 65 years of age – a maximum dose of 440 mg per day. The dose may need to be reduced in people with severe kidney, liver or heart failure.

Anapran neo and contraindications and warnings

Anapran Neo is contraindicated in:

1. hypersensitivity to any component of the preparation or other non-steroidal anti-inflammatory drugs;
2. asthma, rhinitis or nasal polyps;
3. active or past peptic ulcer disease of the stomach and duodenum;
4. hemorrhagic diathesis;
5. severe renal, hepatic or heart failure;
6. III trimester of pregnancy, breastfeeding period.

Anapran Neo – warnings

1. Due to the risk of side effects, patients on long-term use of non-steroidal anti-inflammatory drugs should regularly attend check-ups.
2. In the elderly, the risk of side effects increases (the lowest effective dose of Anapran neo should be used for the shortest possible time).
3. Tell your doctor about any unusual gastrointestinal symptoms (especially bleeding), especially in the early stage of taking Anapran neo. This is especially true for the elderly and people with gastrointestinal diseases. There is a risk of gastrointestinal haemorrhage or perforation, which may be fatal and may not necessarily be followed by warning symptoms.
4. Due to the increased risk of serious side effects, the concomitant use of other preparations containing naproxen, other non-steroidal anti-inflammatory drugs (including selective COX-2 inhibitors), and glucocorticosteroids should be avoided.
5. If there is a need to use low doses of acetylsalicylic acid or other ulcerogenic drugs at the same time, consult a physician who may consider co-treatment with protective drugs (e.g. misoprostol or proton pump inhibitors).
6. It is necessary to exercise particular caution in people with gastrointestinal diseases (ulcerative colitis, Crohn’s disease) as the symptoms may worsen.
7. People with systemic lupus erythematosus and mixed connective tissue disease are at increased risk of developing aseptic meningitis.
8. Patients with bronchial asthma or with symptoms of allergic reactions after taking acetylsalicylic acid (due to the risk of sudden bronchospasm), as well as people taking other medications (especially drugs that lower blood pressure, diuretics, cardiac and psychotropic or anticoagulants) should consult a doctor. before using naproxen.
9. All visual disturbances and eye discomfort should be reported to your doctor.
10. Long-term use of some non-steroidal anti-inflammatory drugs in high doses may increase the risk of heart attack or stroke due to arterial embolism; data on the use of low doses of naproxen (220-660 mg / day) are insufficient to establish their effect on the risk of blood clots.
11. People driving motor vehicles should be especially careful because the drug may cause side effects that impair psychophysical fitness (drowsiness, dizziness and headaches, blurred vision, reduced ability to respond to external stimuli).
12. The preparation contains lactose and should not be used by people with hereditary disorders of galactose intolerance, lactase deficiency or malabsorption of glucose-galactose.

Anapran Neo and drug interactions

Anapran Neo should not be used concomitantly with the following medicines:

1. acetylsalicylic acid or other antiplatelet drugs and SSRI antidepressants – the risk of gastrointestinal bleeding increases;
2. diuretics – non-steroidal anti-inflammatory drugs may reduce the effectiveness of these drugs (e.g. furosemide) and increase the risk of hyperkalemia;
3. antihypertensive drugs – non-steroidal anti-inflammatory drugs may reduce the effectiveness of these drugs (e.g. propranolol and other blockers) and increase the risk of renal failure associated with the use of angiotensin converting enzyme inhibitors;
4. anticoagulants (warfarin, acenocoumarol, heparin) – non-steroidal anti-inflammatory drugs may increase the effect of anticoagulants and increase the risk of bleeding;
5. lithium, methotrexate – non-steroidal anti-inflammatory drugs may increase their plasma concentration and thus increase their toxic effect;
6. cardiac glycosides; cyclosporine or tacrolimus – the risk of nephrotoxicity increases;
7. zidovudine – the bleeding period increases;
8. corticosteroids – the risk of gastrointestinal side effects (e.g. bleeding) increases;
9. the use of antacids, cholestyramine or food intake may delay the absorption of naproxen, but it does not change the total amount absorbed;
10. naproxen increases the risk of symptoms of an overdose of hydantoin, anticoagulants, sulfonamides;
11. due to the potential for interactions between NSAIDs and anticoagulants and sulphonylureas, caution should be exercised;
12. non-steroidal anti-inflammatory drugs used in the period of 8-12 days after the administration of mifepristone may reduce its effectiveness;
13. the use of non-steroidal anti-inflammatory drugs and quinolone drugs increases the risk of seizures;
14. the adrenal function test should be performed at least 48 hours after the administration of naproxen as it may falsify the results of laboratory tests.

Anapran Neo – side effects

Diarrhea, indigestion, abdominal pain, nausea, constipation, flatulence, heartburn, gastritis, peptic ulcer disease, gastrointestinal bleeding, vomiting blood, tarry stools, skin rashes, itching, hives, swelling may occur after taking Anapran Neo. angioedema, renal failure, headache and dizziness, insomnia, somnolence, agitation, irritability, in isolated cases tinnitus or psychotic reactions, convulsions.

Occasional side effects include: respiratory reactions manifested by asthma, worsening of asthma, bronchospasm, or shortness of breath; swelling of the face, tongue, larynx; fatal anaphylactic shock; Heart arythmia; hypertension; heart failure, swelling, vasculitis; blurred vision; muscle pain or weakness; skin reactions in the form of toxic epidermal necrolysis, Stevens and Johnson syndrome, erythema multiforme, systemic lupus erythematosus, pemphigus, purpura, ecchymosis, hemorrhagic diathesis; porphyria; thrombocytopenia; agranulocytosis (the first symptoms are fever, sore throat, mouth ulcers, flu-like symptoms, epistaxis, bruising, ecchymosis, etc.); hemolytic or aplastic anemia; exacerbation of colitis and Crohn’s disease; inflammation of the pancreas; liver dysfunction, jaundice; renal failure, decreased urine output, papillary necrosis, glomerulonephritis, increased plasma sodium, proteinuria, haematuria.

Isolated cases of symptoms associated with aseptic meningitis have been reported in people with autoimmune diseases (e.g. lupus erythematosus). Long-term use of non-steroidal anti-inflammatory drugs in high doses may increase the risk of heart attack or stroke.