Stress has a destructive effect on the body’s work. This is confirmed by further scientific studies. The authors of one recent experiment report that stress also alters the function of the immune system and increases the risk of infection.
- An article appeared in the pages of Nature, the authors of which explain how stress reduces the organism’s ability to defend itself against viruses
- Numerous changes in the functioning of the immune system were observed in mice that experienced severe stress
- According to the authors of the study, the described reactions may be important not only for fighting infection, but also for e.g. cardiovascular health
- More information can be found on the Onet homepage
Mice subjected to rapid stress became less resistant to COVID-19 and the flu – they fought the disease less well and died more often. The authors of this experiment also described how the stressed brain changes the functioning of the immune system.
Scientists from Mount Sinai School of Medicine have shown in the prestigious journal Nature, how stress deteriorates the body’s ability to defend itself against viruses.
They analyzed the work of the organisms of two groups of mice – relaxed and stressed. Within minutes, the rodents that experienced acute stress showed severe changes in the functioning of the immune system.
The periventricular regions of the hypothalamus, with the help of compounds called chemokines, caused leukocytes to move from the lymph nodes into the blood and bone marrow.
The rest of the article is available under the video.
At the same time, the areas of the brain responsible for controlling movement triggered the movement of other immune cells from the marrow into the blood. This discovery was made possible by modern research methods, such as optogenetics and chemogenetics. The stressed mice became less resistant, and after exposure to influenza viruses and SARS-CoV-2, they more often suffered from complications and died.
According to the authors of the study, the described reactions may be important not only for fighting infection, but also for e.g. cardiovascular health. The discovery therefore indicates the need to take care of the mental sphere in order to protect against diseases of the body.
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«This work shows us that stress has a strong impact on our immune system and its ability to fight infection. Thus, many questions arise about how our socioeconomic status, lifestyle and our environment affect the body’s ability to defend itself against infection, ”emphasizes Dr. Filip Swirski, director of the Cardiovascular Research Institute at the Icahn School of Medicine in Mount Sinai.
«Now we need a better understanding of the long-term effects of stress. It will be particularly important to study how we can build resistance to stress and whether it can reduce its negative impact on the immune system »- noted the specialist.
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More information: https://www.nature.com/articles/s41586-022-04890-z (PAP)
Author: Marek Matacz
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