Syn .: Acquired blood coagulation disorders.
Def .: Blood coagulation disorders occurring in the course of various diseases and pathological conditions. Coagulation disorders due to vitamin K deficiency, coagulation disorders in liver diseases, pathological coagulation inhibitors and acquired deficiencies of one clotting factor.
Epid .: They occur in both sexes.
Clinical: Bleeding from the nose and gums, subcutaneous haemorrhages, haematuria, gastrointestinal and trauma bleeding.
DL: In vitamin K deficiency: prolonged PT, normal or slightly prolonged APTT, normal TT and bleeding times. In liver diseases: prolonged PT time, decreased activity of factor V and VII with normal or increased activity of factor VIII, thrombocytopenia.
But: In blood coagulation disorders caused by vitamin K deficiency, treatment consists of administering vitamin K1. In liver diseases, the treatment of coagulation disorders consists in the transfusion of frozen plasma, cryoprecipitate and vitamin K1.
Lit.: [1] Vadikolia C.M., Riddell A., Brooks S. i wsp.: Acquired haemophilia masked by warfarin therapy. Int J Lab Hematol 2007, 29; 64-8. [2] Franchini M., Lippi G.: Acquired von Willebrand syndrome: an update. Am J Hematol 2007, 82; 368-75.
Source: A. Kaszuba, Z. Adamski: “Lexicon of dermatology”; XNUMXst edition, Czelej Publishing House