A breakthrough in the treatment of cancer is on the way. By testing the mice, researchers determined which protein is responsible for the rate of development of lung, blood, and breast cancer. In humans, exactly the same mechanism works, so the new findings will allow to design more effective methods of treatment, and maybe get rid of these diseases forever.
Lung cancer is the most common malignant type of this oncological disease in Poland. According to the data of the Lung Cancer Association, 22 thousand people suffer from lung cancer in Poland every year. people (15 thousand men and 7 thousand women). For 15 percent cases (approx. 3,3 thousand) corresponds to small cell carcinoma.
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Small cell carcinoma – symptoms
Small cell lung cancer usually follows many years of smoking, and the first symptoms of the disease are non-specific.
Its symptoms may include:
- general weakness, weight loss and malaise;
- redness and swelling of the face, widening of the veins in the neck and chest, congestion of the mucous membranes and conjunctiva, headaches and visual disturbances;
- degeneration of the cerebellar cortex, manifested by nystagmus, impaired balance, motor coordination and speech;
The results of the research, recently published in the journal Science Advance, are very promising for patients. By studying genetically modified mouse models, scientists found that EP300 — protein encoded by the EP300 gene – may accelerate or inhibit the development of small cell carcinoma. The discovery could also have implications for other types of cancer. According to the authors of the study, “EP300 mutations are widespread and have been found to play a key role in other cancers, including leukemia and breast cancer”. Now scientists need to learn how to properly model the human protein.
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— This study highlights a potential susceptibility to small cell lung cancer that could be used in the future with new targeted drugs. However, more research will be needed to confirm these results and develop a new treatment approach — Charles Evans, an oncologist, explains in an interview with medicalnewstoday.com.
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