A breakthrough in medicine. An effective vaccine for malaria, one of the world’s deadliest diseases, has emerged

Scientists in Oxford have developed a vaccine against malaria that reached the WHO threshold of 75 efficacy. This is a groundbreaking discovery. Malaria is still one of the most dangerous infectious diseases in the world, and so far scientists have failed to develop an effective preparation. Annually, more than 400 die from malaria. people in the world, mainly children.

1. The world has been busy fighting the coronavirus for over a year, but it must not be forgotten that other infectious diseases are still taking a deadly toll
2. This is mostly true for malaria. Last year, several times more people (384) died of it in Africa than due to COVID-19 (official data indicate 121 deaths)
3. So far, attempts to develop an effective vaccine against malaria have been unsuccessful. The breakthrough has just come
4. Researchers at the University of Oxford have invented a vaccine that has been found to be 77 percent effective in clinical trials. Importantly, no side effects were found
5. More current information can be found on the Onet homepage

Vaccine against malaria – it’s a breakthrough

The new malaria vaccine, developed by scientists at the University of Oxford and their partners, is the first to achieve the efficacy level required by the World Health Organization (WHO) of 75%.

This is a breakthrough in medicine. Malaria is one of the most dangerous infectious diseases in the world. It affects several hundred million people every year, mainly in Africa. Several hundred thousand die, making malaria one of the most common causes of death on Earth.

Scientists tested the malaria vaccine for safety and effectiveness in 450 children aged 5 to 17 months. A randomized, controlled, double-blind phase IIb study was performed at the Clinical Research Unit of Nanoro (CRUN) / Institut de Recherche en Sciences de la Santé (IRSS) in Burkina Faso.

The children were divided into 3 groups: the first group received a high dose of malaria vaccine, the second group received a low dose of malaria vaccine, and the control group received a rabies vaccine.

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A Phase II b clinical trial showed that the malaria vaccine from Oxford University was 12% effective after a 77-month follow-up period. at the higher dose and 71 percent. at a lower dose. No adverse side effects were noted and the vaccine was well tolerated.

The results were published in the prestigious Lancet journal, so far in a preprint, that is, a preliminary version of a scientific publication. This still requires verification, but the first conclusions are encouraging.

An unprecedented level of effectiveness

These are very promising results showing unprecedented levels of vaccine efficacy that have been well tolerated in our research program. We look forward to the upcoming Phase III trial to demonstrate vaccine safety and efficacy data on a larger scale, said Halidou Tinto, professor of parasitology, director of the IRSS in Nanoro and lead author of the study.

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Recruitment for phase III clinical trials is now starting. They will be carried out in four countries, 4 people will take part in them. 800 children aged 5 to 36 months. If the results are also positive, it will mean that the medical world finally has an effective vaccine against malaria.

Despite global efforts to combat malaria, this disease continues to kill too many lives, especially infants and young children. Vaccines can change this. This is a very promising result showing the high efficacy of a safe, cheap and scalable vaccine for children who are most at risk from the devastating effects of malaria, said Lynsey Bilsland of Wellcome, the UK charity that helped fund the research.

While more research is required, this is a significant and exciting step forward in addressing the critical global health challenge, added Bilsland.

Malaria — the facts

Malaria (malaria) is considered to be one of the most dangerous diseases transmitted by parasites to humans. This disease is caused by parasites plasmodium. Parasites are transmitted to humans through the bites of infected female mosquitoes Anopheles, called “malaria vectors”.

There are five species of parasites that cause malaria in humans, two of them – falciparum i P. vivax – are the greatest threat.

According to a WHO report on the disease, there were 2019 million cases of malaria worldwide in 229. 409 thousand died people. In 2018 it was 228 million and 405 thousand, respectively, while in 2017 – 231 million and 416 thousand.

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The data for 2020 says about 384 thousand. victims in Africa itself. The African region still accounts for a disproportionate share of the global malaria burden. In Africa, there is 94 percent. all illnesses and deaths.

Children under the age of 5 are most at risk of malaria – in 2019, they accounted for 67%. (274) of all malaria deaths worldwide.

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