Contents
Actovegin is produced in the form of tablets and solution for injection. The active substance in the composition of the drug is calf blood components that affect tissue metabolism, protect nerve cells from damage and improve microcirculation1.
Актовегин применяют для лечения:
- cognitive impairment due to stroke or dementia;
- circulatory disorders in the limbs;
- diabetic polyneuropathy1.
Actovegin is contraindicated for use in patients:
- with hypersensitivity to the components of the drug;
- with fructose intolerance, glucose-galactose malabsorption or sugar-isomaltose deficiency;
- under 18 years old.
Actovegin is prescribed to pregnant and lactating women if the potential benefit to the mother outweighs the possible risks to the child. Actovegin rarely causes side effects. Only allergic reactions have been reported1.
The composition contains phenylalanine, so it should not be prescribed to patients with phenylketonuria. It also contains sodium and potassium. This should be taken into account for patients on a diet with a low content of them.
The price of Actovegin depends on the dosage form. For a package of 50 tablets, you will need to pay about 1500 rubles, a package of 5 ampoules will cost 500 rubles.
List of top 7 inexpensive and effective analogues of Actovegin according to KP
With pharmacist, Ph.D. Evgenia Pogorelova we have selected the 7 best analogues of Actovegin. The rating includes drugs with identical composition and Actovegin substitutes with a similar therapeutic effect. The list of analogues of Actovegin includes various dosage forms – tablets, injection solutions, ointments and gels for external use.
1. Solcoseryl
Солкосерил — самый близкий аналог Актовегин, который также содержит в составе компоненты крови молочных телят. Солкосерил имеет больше форм выпуска: глазной гель, мазь, паста и гель для наружного применения, а также раствор для инъекций.
Solcoseryl increases the consumption of oxygen and glucose by cells, improves blood circulation and tissue repair2Therefore, it is used to treat peripheral circulatory disorders, strokes and traumatic brain injuries.2.
Солкосерил противопоказан беременным, кормящим, детям до 18 лет и пациентам с аллергией. Препарат редко вызывает аллергические реакции, однако, перед применением рекомендуют провести аллергопробу. Солкосерил для инфузий нельзя смешивать с растительными препаратами из-за повышения риска развития аллергии.
Solcoseryl cannot be called a budget drug. For example, the price of ointment and gel in different pharmacies varies from 3500 to 4500 rubles.
2. Mexidol
Mexidol is available in the form of tablets and injections and is used as an antioxidant. Mexidol increases the body’s resistance to shock, hypoxia, cerebrovascular accidents and intoxications.3.
The drug is prescribed in the following situations:
- for the prevention of cerebrovascular accidents;
- with traumatic brain injuries;
- encephalopathy;
- VSD;
- cognitive impairment due to atherosclerosis;
- тревожных расстройствах;
- angina pectoris;
- hangover;
- передозировке лекарствами;
- for the prevention of diseases arising from high physical activity;
- under severe stress3.
Мексидол, в отличие от Актовегина, строго противопоказан пациентам с острыми нарушениями работы печени и почек, беременным и кормящим женщинам3. Пациентам, принимающим препарат, следует соблюдать осторожность при управлении транспортом и сложными механизмами.
The average price for a pack of Mexidol tablets or ampoules is about 400 rubles.
3. Elkar
The drug is produced in the form of granules, oral solution and injection solution. Elcar is a drug of the metabolic drug levocarnitine. It increases resistance to physical stress, improves metabolism and provides tissues with energy.4.
Элькар используют в следующих случаях:
- with increased physical and emotional stress;
- в лечении хронического гастрита и панкреатита;
- for the treatment of skin diseases;
- with hypothyroidism;
- in the treatment of neurological symptoms in brain damage;
- для восстановления мышц, увеличения мышечной массы и уменьшения процента жира у спортсменов4.
Элькар, в отличие от Актовегина, противопоказан только при повышенной чувствительности к компонентам препарата. Однако у Элькара больше побочных эффектов, среди которых аллергия, тошнота и боль в животе. В отличие от предыдущих аналогов, препарат не влияет на скорость реакции, поэтому без ограничений может применяться людьми, которые управляют автомобилями и сложными механизмами.
Цена Элькар зависит от лекарственной формы. Например, 100 мл раствора для приема внутрь будут стоит от 550 до 750 рублей.
4. Акатинол Мемантин
Akatinol is a drug based on memantine hydrochloride, which is used to treat dementia, improve cognitive function and increase daily activity.5. Препарат выпускают только в форме таблеток.
Acatinol Memantine is contraindicated in:
- hypersensitivity to the components of the drug;
- severe renal or hepatic impairment;
- pregnancy and lactation;
- under the age of xnumx.
The drug often causes side effects: headache, drowsiness, increased blood pressure, shortness of breath, constipation, dizziness5, therefore, when taking it, it is better to refrain from driving.
The price for a pack of 30 Akatinol Memantine tablets is 1700-2000 rubles. The package is enough for about a month of treatment.
5. Recognized
Recognan is a nootropic drug based on citicoline, which is available as a solution for injection and oral administration. Recognan has an antioxidant effect, restores damaged cells and prevents their death. The drug reduces the area of brain damage in stroke and improves the transmission of nerve impulses, reduces the strength of neurological symptoms and speeds up the recovery of the patient6.
Recognan is prescribed for:
- complex treatment of ischemic stroke;
- recovery after an ischemic or hemorrhagic stroke;
- complex treatment of the consequences of traumatic brain injury and recovery of the patient;
- treatment of cognitive and behavioral disorders6.
The drug is contraindicated in patients with hypersensitivity to the components, children under 18 years of age. Pregnant women are prescribed with caution under the supervision of a physician. At the time of Recognan’s use it is necessary to stop breastfeeding.
Recognan, like Actovegin, rarely causes side effects. Among them, only allergic reactions and changes in blood pressure were registered. During treatment, care must be taken when driving and operating mechanisms.
The average price for 100 ml of oral solution is 1400 rubles. This volume is enough for 7-10 days of treatment.
6. Никотиновая кислота
Nicotinic acid is available in the form of tablets and injections. This is a vitamin that is necessary for the normal functioning of the brain, intestines and skin. Nicotinic acid dilates blood vessels, improves the metabolism of carbohydrates and fats and improves microcirculation and gas exchange in tissues7. It is used in combination therapy for the same indications as Actovegin:
- ischemic stroke;
- peripheral circulatory disorders;
- diabetic polyneuropathy7.
Никотиновая кислота противопоказана пациентам с обострением язвы желудка или кишечника, подагрой, гепатитами, циррозом печени и декомпенсированным сахарным диабетом. С осторожностью назначают в период ремиссии гастрита, язв ЖКТ, беременности, лактации и детям до 18 лет7.
Nicotinic acid causes more side effects than Actovegin. The most common of them: redness and a feeling of a rush to the scalp, decreased pressure, headache, dizziness, pain at the injection site, allergic reactions.
При длительном применении препарат вызывает жировую дистрофию печени и изменение лабораторных показателей крови. Для профилактики осложнений со стороны печени рекомендуется употреблять творог, использовать препараты метионина и липоевой кислоты. На время лечения никотиновой кислотой следует воздержаться от управления транспортом.
Nicotinic acid is inexpensive – for example, for a pack of 50 tablets, you will need to pay about 50 rubles. For a month of treatment, on average, 2 packs are required.
7. Glycine
Amino acid Glycine improves metabolism in brain tissues, reduces psycho-emotional stress, improves mood, normalizes sleep, increases mental performance, reduces the severity of disorders after a stroke and head injury, reduces the toxic effects of alcohol8.
The drug has a wider list of indications than Actovegin, and includes the same brain disorders after strokes and head injuries, encephalopathies8. But it is not used to improve peripheral circulation.
Glycine from different manufacturers has different recommendations for use in pregnant and lactating women. Someone strictly forbids, and someone recommends using with caution under the supervision of a doctor. But the drug is approved for use in children from 3 years.
Glycine has a narrower list of contraindications compared to Actovegin: only hypersensitivity to the components of the drug. Side effects include allergic reactions.
Glycine refers to budget drugs. The price for a pack of 50 tablets from different manufacturers varies from 50 to 120 rubles. There are more expensive options – with accelerated action, in combination with vitamins and plant extracts.
How to choose an analogue of Actovegin
– When choosing a replacement for the drug, preference should be given to the closest analogue – the one that contains the same active substance. The closest analogue of Actovegin is Solcoseryl. Actovegin can be replaced with other analogues only after consulting a doctor, advises a pharmacist, Ph.D. Evgeny Pogorelova.
Reviews of doctors about analogues of Actovegin
– In Russia, Actovegin and its analogues are prescribed quite often. But it is worth noting that there have been very few qualitative studies of Actovegin and its analogues. And the results obtained, according to the authors, require further confirmation. Therefore, many doctors, with similar indications, prescribe other means instead of Actovegin, the expert notes.
Popular questions and answers
How to use Actovegin analogues correctly and whether it is safe to switch to a replacement, answers the pharmacist, Ph.D. Evgeny Pogorelova.
When can Actovegin analogs be used?
What will happen if you stop using Actovegin and switch to an analogue?
Sources of:
- Vidal. Reference book of medicines. Actovegin. https://www.vidal.ru/drugs/actovegin__28
- Vidal. Reference book of medicines. Solcoseryl. https://www.vidal.ru/drugs/solcoseryl__8913
- Видаль. Справочник лекарственных средств. Мексидол. https://www.vidal.ru/drugs/mexidol__32969
- Видаль. Справочник лекарственных средств. Элькар. https://www.vidal.ru/drugs/elcar__25460
- Vidal. Reference book of medicines. Akatinol Memantine. https://www.vidal.ru/drugs/akatinol_memantine__33451
- Vidal. Reference book of medicines. Recognan. https://www.vidal.ru/drugs/recognan__44998
- Видаль. Справочник лекарственных средств. Никотиновая кислота. https://www.vidal.ru/drugs/nicotinic_acid__41962
- Vidal. Reference book of medicines. Glycine. https://www.vidal.ru/drugs/glycine__4429