10 best choleretic drugs
Pain in the right hypochondrium, bitterness in the mouth, nausea, yellow skin – all these are clear signs of a violation of the liver and gallbladder. Here, choleretic drugs come to the rescue, which will improve the production and outflow of bile and restore good health.

Digestion is a complex and important process in our body. The well-coordinated work of the digestive tract is responsible for literally everything – from general well-being to the beauty of the skin and hair. One of the main “workers” of digestion is the liver. It produces bile, which helps break down and absorb fats, activates the production of digestive enzymes, and is involved in the absorption of vitamins.

But for storage, bile is sent to the gallbladder. The following symptoms indicate a malfunction in the work of this organ1:

  • discomfort or pain in the right hypochondrium;
  • nausea;
  • bitterness in the mouth;
  • bloating;
  • yellowing of the skin;
  • discoloration of feces.

Choleretic drugs are used to improve the functioning of the liver and gallbladder1. They are of two types:

  1. aimed at enhancing the production of bile (choleretics or cholesecretics);
  2. stimulating the excretion of bile from the gallbladder into the intestines (cholekinetics).

The division into groups is arbitrary, since most drugs have a complex effect. Many effective choleretic drugs are available and sold in pharmacies without a doctor’s prescription. However, do not forget that taking choleretic drugs has many contraindications, so you should definitely consult a doctor before taking them.   

Rating of the top 10 inexpensive and effective choleretic drugs according to the KP.

Together with an expert, we have compiled a rating of inexpensive and effective choleretic drugs. The rating was based on the availability and effectiveness of the drug, the form of release and the mechanism of action.

1. Allahol

Probably, it is Allochol that is the most popular choleretic agent among the people. It contains dry bile of cattle, activated charcoal, garlic and nettle. Allochol not only saturates bile and stimulates its formation, but also enhances intestinal motility, has an antimicrobial effect and is a good sorbent.

You need to take the drug 2 tablets after meals, 3-4 times a day. The course of treatment is 3-4 weeks. You can spend 2-3 courses of treatment with a break of 3 months.

Contraindications: gallstones, acute pancreatitis and hepatitis, stomach and duodenal ulcers.

completely natural product, minimum side effects, affordable price.
long-term use is required to achieve the effect.
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2. Choleenzyme

Another popular choleretic agent on a natural basis. In addition to dry bile, it contains components of the intestinal mucosa and pancreas of cattle. The drug also normalizes the digestive process, improves the functioning of the gastrointestinal tract, and helps the absorption of protein.

Doctors recommend Cholenzim for chronic gastritis, colitis, cholecystitis, pancreatitis, as well as for people who lead a sedentary lifestyle and have frequent dietary errors. The drug should be taken 1 tablet 3 times a day after meals.

Contraindications: individual intolerance to the components, acute pancreatitis and jaundice caused by a violation of the outflow of bile.

minimum side effects, consists of natural raw materials, a good prophylactic.
contraindicated in children under 12 years of age, may cause an allergic reaction.
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3. Hofitol

This French representative of choleretic agents contains only artichoke herbal raw materials. The drug has a bright choleretic and diuretic effect, supports the normal functioning of the liver. Under the supervision of a doctor, Hofitol can be prescribed to children and pregnant women.

Hofitol is available in the form of tablets and oral solution. You need to take it 2-3 tablets 3 times a day before meals. The course of treatment is 2-3 weeks.

Contraindications: hypersensitivity to the components of the drug, cholelithiasis, obstruction of the biliary tract, acute diseases of the liver, kidneys.

natural herbal composition, pronounced choleretic effect.
high drug price.
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4. No-shpa

No-shpa (drotaverine) is the most famous antispasmodic. The drug relieves spasms of smooth muscles of internal organs, in particular the biliary tract. This is due not only to its analgesic, but also to the choleretic effect. No-silo can be bought at almost any pharmacy without a doctor’s prescription, as it has very few contraindications and side effects.

Contraindications: hypersensitivity to components, severe hepatic or renal insufficiency, children under 6 years of age.

acts comprehensively, eliminates spasm and pain, affordable price.
can cause allergies, there is a threat of overdose.

Pros: acts comprehensively, eliminates spasm and pain, affordable price.

Cons: can cause allergies, there is a threat of overdose.

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5. Magnesium sulfate

The drug Magnesium sulfate, better known as magnesia, is a remedy with a choleretic and laxative effect. Magnesia has a very strong bitter-salty taste, which makes taking the drug extremely unpleasant. But the effect comes very quickly, after the first dose.

Magnesia is produced in the form of bags of powder, which must be dissolved in a glass of water. It is taken 1-3 times a day between meals.

Contraindications: diarrhea, heart disease, acute inflammatory processes in the gastrointestinal tract, renal failure, pregnancy.

pronounced choleretic effect, low price.
very unpleasant taste, strong laxative effect, not suitable for long-term use.

6. Sorbitol

Sorbitol (sorbitol) is the most delicious drug with a choleretic effect. It is a six-hydric alcohol, a popular sugar substitute. In addition to the choleretic properties, it generally improves digestion, helps to remove toxins.

The drug is available as a sweet powder in packages of 500 g. It is used in 5-10 g (1-2 teaspoons) 2-3 times a day.

Contraindications: hypersensitivity to the drug, fructose intolerance, ascites, colitis, irritable bowel syndrome.

natural sugar substitute, good choleretic effect, improves digestion.
can not be taken constantly, has a laxative effect, can cause flatulence and pain in the stomach.
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7. From Sibek

Sibektan is a domestic phytopreparation of complex action. The composition contains extracts of birch, St. John’s wort, tansy and milk thistle. In addition to the choleretic action, the drug works as a hepatoprotector, protecting liver cells. Sibektan is prescribed for biliary dyskinesia, chronic hepatitis and chronic cholecystitis.

You need to take the drug 2 tablets 4 times a day, 30-40 minutes before meals.

Contraindications: cholelithiasis, fructose intolerance. Not intended for children, pregnant women and nursing mothers.

good choleretic effect, protects and restores liver cells.
contraindicated in childhood and pregnancy, may cause allergic reactions.
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8. Holosas

Holosas is a fairly well-known herbal preparation that is available in the form of a sweet syrup. It is based on an extract of rose hips, which has a pronounced choleretic effect. In addition, it is rich in vitamin C and has a general strengthening effect. Another advantage of the syrup is the improvement of intestinal motility. Holosas is also prescribed for drug poisoning and alcohol intoxication.

The syrup should be taken 1 teaspoon 3-4 times a day, half an hour before meals.

Contraindications: hypersensitivity to the components of the drug, pregnancy, lactation, children under 12 years of age.

natural composition, has a pleasant taste, good choleretic effect, compensates for the lack of vitamin C.
a small volume of the vial, with a fairly low price per vial, the cost of a course of treatment is high.
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9. Phytohepatol

Phytohepatol (phytohepatol, choleretic collection No. 3) is a drug with a completely herbal composition. As part of the collection: peppermint, chamomile flowers, tansy, yarrow and calendula. It has choleretic, anti-inflammatory, antispasmodic and antibacterial properties. Phytohepatol improves the general condition of the liver, gallbladder and gastrointestinal tract.

The only inconvenience is the rather troublesome preparation. First you need to prepare the infusion for 15 minutes in a water bath, and then insist another 45 minutes.

Take the infusion should be 100 ml, 3 times a day for 30-40 minutes before meals. The course of treatment is 2-4 weeks.

natural composition, fast effect, pleasant taste.
difficulty in preparing the infusion.
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10. Odeston

Odeston is a synthetic preparation of Polish production. It has pronounced choleretic properties, eliminates stagnation of bile, prevents the formation of stones in the gallbladder. The drug has proven itself in the treatment of biliary dyskinesia. It is also prescribed by doctors after operations on the gallbladder and biliary tract.

Odeston should be taken 1 tablet 3 times a day, 30 minutes before meals, for 2-3 weeks.

Contraindications: hypersensitivity, biliary tract obstruction, Crohn’s disease, gastric and duodenal ulcer, hemophilia, age up to 12 years.

good choleretic effect.
an expensive course of treatment, complications are possible in the form of abdominal pain, diarrhea, flatulence.
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How to choose choleretic drugs

Before choosing a choleretic drug, be sure to consult your doctor. Often, violations of bile secretion are caused by inflammatory diseases of the liver and biliary tract, as well as the presence of stones in the gallbladder and ducts. In this case, self-medication is not only ineffective, but also dangerous.2.

Like any remedy, effective choleretic drugs have a number of contraindications. You should not self-medicate if you have a stomach or duodenal ulcer. Inflammation of the pancreas is also a contraindication.

Before buying, read the possible side effects and contraindications. Many drugs should not be taken by children, some are indicated only from the age of 18.

Evaluate the naturalness of the composition of a particular drug, the recommended duration of administration. Think about how it is more convenient for you to take a choleretic drug: before or after meals, in tablets, capsules, syrup, infusion? When choosing an inexpensive choleretic drug, pay attention to the volume of the package. It is not always enough for the entire course of treatment.

Reviews of doctors about choleretic drugs

According to gastroenterologists, the independent use of choleretic drugs should be treated very carefully. Before taking the drug, you need to find out the cause of the violation of the outflow of bile. For example, with cholelithiasis, taking choleretic drugs can be very dangerous.2. In addition, choleretic drugs have a debilitating effect on liver cells, so their long-term use must be combined with the use of hepatoprotectors.3.

According to our expert endocrinologist-nutritionist Maria Kodyakova, in any case, the appointment of effective choleretic drugs is the business of a professional doctor. Do not neglect the advice of a gastroenterologist, do not self-medicate.

Popular questions and answers

How choleretic drugs work and why they are generally prescribed, we asked endocrinologist-nutritionist Maria Kodyakova.

How do choleretic drugs work?

– According to the principle of action, choleretic drugs can be divided into 3 main groups:

• choleretics – drugs that stimulate the formation of bile. They may contain natural bovine bile, synthetic substitutes, or herbal extracts that increase the amount of bile produced;

• cholekinetics – drugs that increase the excretion of bile;

• cholespasmolytics – relax the smooth muscles of the biliary tract, facilitate the movement of bile and relieve spasms.

Why drink choleretic drugs?

– Choleretic drugs are taken to eliminate unpleasant symptoms associated with insufficient bile flow. These symptoms are well known to many: discomfort or pain in the right hypochondrium, nausea, bitterness in the mouth, bloating, yellowing of the skin. They can be both temporary (associated with malnutrition) and indicate serious disorders in the functioning of the digestive system. The cause of the violations can be determined by a gastroenterologist.

How to take choleretic drugs?

– Schemes for taking choleretic drugs may differ from each other depending on the mechanism of action. Preparations containing bile (for example, Allochol) and its substitutes are taken after meals. Herbal preparations (for example, Holosas, rosehip preparations), which stimulate the formation of bile, are taken half an hour before meals. Do not forget that there are non-pharmacological means of preventing disorders (for example, gallbladder intubation or exercise therapy). In any case, the dosage regimen will be determined by your doctor.

Sources:

  1. Yakovenko E.P., Agafonova N.A. “Diseases of the Digestive Organs”. Appendix BC “Diseases of the Digestive Organs” No. 1 dated 03.05.2005. https://www.rmj.ru/articles/bolezni_organov_pishchevareniya/Mehanizmy_ghelcheobrazovaniyai_ghelchegonnye_preparaty/
  2. Mashkovsky M.D. Medicines in 2 volumes. Volume No. 2. M., 2000. – p. 540. https://www.studmed.ru/mashkovskiy-md-lekarstvennye-sredstva-v-2-t-tom-2_808dd8b7c10.html
  3. Diseases of the liver and biliary tract: A guide for physicians. V.T. Ivashkin. M., 2002. – p. 416. https://kingmed.info/knigi/Gastroenterologiya/book_490/Bolezni_pecheni_i_jelchevyvodyashchih_putey-Ivashkin_VT-2002-chm

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