10 best analogues of Ursosan
Ursosan has long been successfully used to treat diseases of the liver and biliary tract. The rather high price of the original drug and the frequent lack of sales is the main reason for the interest in its replacements. Together with an expert, we will select Ursosan analogues and find out how to use them correctly

The active ingredient of Ursosan is ursodeoxycholic acid. It protects liver cells from toxins, stimulates the outflow of bile, dissolves cholesterol stones, lowers blood sugar and cholesterol, improves the functioning of the stomach and pancreas. Ursosan is prescribed for cholelithiasis, chronic hepatitis, biliary dyskinesia and other diseases of the liver and gallbladder.

The Czech drug is produced in capsules with a dosage of 250 mg (Ursosan) and tablets of 500 mg (Ursosan Forte). The dosage and regimen should be selected by the doctor. The duration of therapy on average ranges from several months to a year.

Rating of the top 10 inexpensive and effective analogues of Ursosan according to KP

Together with an expert, we have selected the 10 best analogues of Ursosan, which are in the pharmacy chain. The list of analogues includes drugs based on ursodeoxycholic acid, as well as drugs with other active ingredients, but with a similar effect.

Note that our rating is intended for information only, and only a doctor can choose the best analogue of Ursosan.

1. Urdu

The Russian analogue of Ursosan contains ursodeoxycholic acid and has a similar effect. Urdox improves the outflow of bile, promotes the dissolution of cholesterol stones, restores the structure of liver cells of hepatocytes1. Suitable for adults and children over 3 years of age1. Available in capsules with a dosage of 250 mg.

Urdox should not be used for serious disorders in the functioning of the kidneys, liver and pancreas, acute inflammation of the gallbladder and intestines, in the presence of stones with a high calcium content in the gallbladder and ducts1.

like Ursosan, contains ursodeoxycholic acid; costs less than the original; well tolerated by most patients.
the need to take a large number of capsules daily – from 3 to 6 pieces.

2. Ursofalk

An analogue of Ursosan from a German manufacturer contains ursodeoxycholic acid and is available in capsules with a dosage of 250 mg and tablets with a dosage of 500 mg. Ursofalk helps dissolve cholesterol gallstones and has a hepatoprotective effect: it reduces the toxicity of bile salts and protects against liver cell damage. The dose of the drug and the duration of administration are selected by the doctor, but on average, adults should take from 3 to 6 capsules daily.

Ursofalk should not be taken with obstruction of the biliary tract, acute inflammation of the gallbladder and intestines, frequent attacks of biliary colic, during pregnancy and with individual intolerance to the components.

full analogue of Ursosan on the active substance; drug from a well-known manufacturer.
high price in the segment.

3. Exhol

Another drug from a Russian manufacturer. The composition is similar to Ursosan and contains ursodeoxycholic acid. Available in capsules (250 mg) and tablets (500 mg)2. This hepatoprotective (protecting the liver) and choleretic agent is used for cirrhosis of the liver, biliary dyskinesia, to dissolve cholesterol stones.2.

Contraindications for Exhol are the same as for other drugs of ursodeoxycholic acid. It should not be prescribed to people with obstruction of the biliary tract, renal and hepatic insufficiency, in the presence of gallstones with a high calcium content.2.

a drug with the same active ingredient as Ursosan; two dosage options; high efficiency.
not sold in all pharmacies.

4. Hofitol

Hofitol tablets contain 0,2 g of purified field artichoke extract, which has a hepatoprotective and choleretic effect, improves metabolism3. Hofitol is prescribed for biliary dyskinesia, chronic non-calculous cholecystitis, hepatitis and cirrhosis of the liver.3. However, unlike Ursosan, this drug is not used for cholelithiasis.

Hofitol is contraindicated in the presence of stones in the gallbladder and ducts, in acute diseases of the liver, kidneys and biliary tract, with individual intolerance to the components3.

natural composition; suitable for children from 6 years old; efficacy noted by many patients.
does not dissolve cholesterol stones.
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5. Heptral

Heptral protects and restores liver cells, improves the synthesis and outflow of bile, which makes it possible to attribute it to Ursosan’s analogues. The drug is used in the complex therapy of chronic acalculous cholecystitis, cholangitis, hepatitis, cirrhosis and toxic liver damage.4. The release form of the drug is tablets with a dosage of 400 and 500 mg.

Heptral can not be used for bipolar disorder, hypersensitivity to any of the components, under the age of 18, with some genetic disorders4.

effective hepatoprotector; can be taken for a long time.
high price in the segment; does not dissolve cholesterol gallstones.

6. Phosphoglyvium

The drug based on phospholipids and glycyrrhizic acid protects and restores hepatocytes – liver cells5. Phosphogliv normalizes the metabolism of proteins and carbohydrates, improves the ability of the liver to neutralize toxins. Used in the treatment of hepatitis, fatty degeneration and cirrhosis of the liver5. Adults should take 1-2 capsules of the drug 3 times a day. The duration of treatment is determined by the doctor.

Phosphogliv should not be used in children under 12 years of age, people with hypersensitivity to the components of the drug and antiphospholipid syndrome, pregnant and lactating women5.

minimum side effects; protects liver cells; suitable for long-term therapy.
does not dissolve gallstones; less active than Ursosan, stimulates bile secretion; daily you need to take a large number of capsules (from 3 to 6).
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7. Essentiale forte

The popular drug contains phospholipids that restore liver cells and improve the composition of bile.6. Used for various diseases and disorders in the liver, prevents the formation of stones in the gallbladder6. The recommended regimen is 2 capsules 3 times a day for 3 months.

Essentiale should not be taken by children under 12 years of age, people with hypersensitivity to its components, lactating women6. Use during pregnancy is possible under medical supervision.

efficiency; protects and restores liver cells; good tolerance.
does not dissolve gallstones.
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8. Karsil

The active component of this hepatoprotector is milk thistle fruit extract. Karsil helps restore liver cells and protects them from harmful substances. The drug is prescribed for people with toxic liver damage, chronic non-viral hepatitis7. It is recommended to take Karsil 1 capsule 3 times a day. The course of treatment is at least 3 months.

There are few contraindications for Karsil – hypersensitivity to the components of the drug, celiac disease, lactase deficiency, pregnancy and breastfeeding7.

natural composition; well tolerated by most patients.
long course of treatment; the effect is not immediately noticeable; the drug does not dissolve gallstones.
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9. Ursodez

The preparation of a Russian manufacturer contains ursodeoxycholic acid and is available in capsules with a dosage of 950 and 500 mg.8. The indications for use and the mechanism of action of Ursodez are the same as those of Ursosan, although the analogue costs approximately 30% cheaper than the original.

Contraindications: renal and hepatic insufficiency, obstruction of the biliary tract, frequent attacks of biliary colic8.

active substance similar to Ursosan; two dosage options are available; almost always available in pharmacies.
can cause nausea, diarrhea, pain in the stomach and right hypochondrium.

10. Odeston Forte

The active substance of Odeston is hymecromon9. The drug stimulates the production and outflow of bile, prevents its stagnation in the gallbladder and ducts, and reduces the likelihood of stone formation. Used for cholangitis, biliary dyskinesia, acalculous cholecystitis9. Reception schedule for adults – 1 capsule three times a day for two weeks.

Contraindications: obstruction of the biliary tract, severe disorders in the functioning of the kidneys and liver, gastric and duodenal ulcers, age up to 12 years, pregnancy and lactation9

effective choleretic agent; well tolerated; one package is enough for a course of treatment.
unlike Ursosan, it does not dissolve cholesterol stones and does not protect liver cells.
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How to choose an analogue of Ursosan

The best analogues of Ursosan are generics, that is, non-original drugs with the same active ingredient: Ursodez, Urdoksa, Exhol, Grinterol. The rest of the drugs from our rating contain other active ingredients and differ from Ursosan in their mechanism of action and therapeutic effect.

For example, Hofitol, Karsil and Essentiale protect and restore liver cells, but do not dissolve gallstones. Many choleretic drugs are contraindicated in cholelithiasis – this must be taken into account when choosing an analogue.

Reviews of doctors about the analogues of Ursosan

Therapists and gastroenterologists prescribe Ursosan analogues for the treatment of uncomplicated cholelithiasis, biliary dyskinesia, chronic hepatitis and cholangitis. Most physicians consider ursodeoxycholic acid generics to be an equivalent replacement for the original drug.

When choosing an analogue with a different mechanism of action, the nature of the disease is taken into account. For example, Essentiale Forte and Heptral can be a worthy replacement for Ursosan in liver diseases.

Popular questions and answers

Most adults have diseases and disorders in the functioning of the liver and biliary tract. Many of them are prescribed Ursosan and its analogues. The most popular questions about the use of these drugs are answered by our expert, pharmacist, head of the pharmacy Yulia Mamulina.

When can Ursosan analogues be used?

– Ursosan analogues are used according to indications, among which there may be chronic liver pathologies, cholelithiasis, cholecystitis, cholangitis, biliary dyskinesia. The drug should be selected by the attending physician, who will take into account the severity and stage of the disease, the general state of human health, the tendency to allergic reactions and other individual characteristics.

What happens if you stop drinking Ursosan and switch to an analogue

“If it’s a generic ursodeoxycholic acid at the same dosage, then most likely nothing will happen. A decrease in the effectiveness of treatment when switching to a new drug is very rare. If we are talking about other analogues of Ursosan, then various negative consequences are possible if the drug is chosen incorrectly. For example, Odeston can provoke an attack of biliary colic in people with gallstone disease.

Sources of:

  1. Register of medicines of Russia. Urdoksa https://www.rlsnet.ru/tn_index_id_41902.htm
  2. Register of medicines of Russia. Exhol. https://www.rlsnet.ru/tn_index_id_50034.htm
  3. Register of medicines of Russia. Hofitol https://www.rlsnet.ru/tn_index_id_3497.htm
  4. Register of medicines of Russia. Heptral. https://www.rlsnet.ru/tn_index_id_965.htm
  5. Register of medicines of Russia. Phosphogliv https://www.rlsnet.ru/tn_index_id_9908.htm
  6. Register of medicines of Russia. Essentiale Forte. https://www.rlsnet.ru/tn_index_id_13197.htm
  7. Register of medicines of Russia. Karsil. https://www.rlsnet.ru/tn_index_id_1685.htm
  8. Register of medicines of Russia. Ursodez. https://www.rlsnet.ru/tn_index_id_48499.htm
  9. Register of medicines of Russia. Odeston. https://www.rlsnet.ru/tn_index_id_99554.htm

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