10 best analogs of Bisoprolol
Bisoprolol is often prescribed for heart disease, however, the drug is not always found in pharmacies, and its price is quite high. Together with a cardiologist, we compiled a list of inexpensive and effective substitutes for Bisoprolol and discussed how and when to take them

Bisoprolol belongs to the group of selective beta-blockers and is used in cardiology for coronary heart disease, chronic heart failure. Often it is prescribed for the treatment of cardiac arrhythmias and hypertension.1.

Bisoprolol reduces the risk of myocardial infarction and death in heart failure. The drug reduces the consumption of oxygen by the heart muscle, dilates the vessels that feed the heart, reduces the frequency of pain attacks and has a positive effect on the prognosis of the disease.2.

Side effects when taking bisoprolol are quite rare. As a rule, they are associated with an incorrectly selected application scheme. Because of this, the patient can greatly reduce blood pressure and drop the pulse. Among other side effects: dizziness, headache, dyspepsia, stool disorders (constipation, diarrhea). The frequency of their occurrence does not exceed 10%.

Bisoprolol is prescribed with the utmost care to patients with bronchial asthma and atherosclerosis of the arteries of the lower extremities. In heart failure, the drug should be taken in minimal doses – 1,25 mg once a day.

List of top 10 analogues and cheap substitutes for Bisoprolol according to KP

1. Concor

Concor is available in tablet form of 5 and 10 mg and contains bisoprolol as an active ingredient. The main effect of the drug is aimed at reducing the heart rate both at rest and during exercise, as well as dilating the arteries of the heart.

Concor is taken 1 time per day in the morning, regardless of food. The action of the drug lasts 24 hours.

Противопоказания: acute and chronic heart failure, cardiogenic shock, sinoatrial blockade, severe bradycardia and arterial hypotension, severe forms of bronchial asthma, age up to 18 years.

the most effective replacement for the original drug, the studied mechanism of action.
quite an extensive list of contraindications.

2. Niperten

Niperten is available in tablet form of 2,5-10 mg and also contains bisoprolol in the composition. The effect of the drug is maximally felt 3-4 hours after ingestion, but the concentration in the blood persists for 24 hours, which ensures a long therapeutic effect. Niperten should be taken once a day in the morning, regardless of the meal.

Противопоказания: acute heart failure, chronic heart failure in the stage of decompensation, cardiogenic shock, collapse, pronounced decrease in blood pressure, severe forms of bronchial asthma and COPD in history, age up to 18 years.

lower price compared to Concor, effect 24 hours.
is not an original product.

3. Bisogamma

Bisogamma also contains bisoprolol and is available in 5 and 10 mg tablets. This is a daily drug – its therapeutic effect lasts for 24 hours.

Begin treatment with a dosage of 5 mg 1 time per day. Then, if necessary, the dosage is increased to 10 mg 1 time per day. The maximum allowable dosage per day is 20 mg. Bisogamma should be taken in the morning before meals.  

Противопоказания: shock (including cardiogenic), pulmonary edema, acute heart failure, chronic heart failure in the stage of decompensation, severe bradycardia, arterial hypotension (especially with myocardial infarction), severe forms of bronchial asthma and other obstructive airway diseases, depression, age up to 18 years.

affordable price.
is not an original drug, a large list of contraindications.

4. Concor Core

Concor Cor is a full-fledged analogue of the Concor drug, as well as an effective replacement for Bisoprolol. The composition also contains the active substance of the same name, and the main difference is in the dosage. Concor Cor is available only in a dosage of 2,5 mg. In addition, the tablets are white, unlike Concor, which has a darker color due to the higher concentration of the active substance.

Противопоказания: hypersensitivity to the components of the drug, acute and chronic heart failure, cardiogenic shock, severe bradycardia and arterial hypertension, severe forms of bronchial asthma, age up to 18 years.

valid 24 hours.
due to the dosage, it is prescribed only for the treatment of chronic heart failure.

5. Coronal

And again, a drug that contains the active substance bisoprolol. Coronal is available in tablets of 5 and 10 mg and is valid for 24 hours. You need to take a tablet 1 time per day in the morning before meals. The maximum daily dose is 20 mg.

Противопоказания: shock (including cardiogenic), acute heart failure and chronic insufficiency, severe bradycardia, cardiomegaly (without signs of heart failure), arterial hypotension (especially with myocardial infarction), bronchial asthma and chronic obstructive pulmonary disease in history, lactation period, age up to 18 years.

affordable price, therapeutic effect lasts 24 hours.
fewer dosage options. Not an original drug.

6. Bisomor

The drug Bisomor also contains bisoprolol and is an inexpensive but effective replacement for the original drug of the same name. Bisomor is available in tablets with a dosage of 2,5, 5 and 10 mg and is valid for 24 hours. Take the drug once a day in the morning before meals. The maximum allowable daily dose is 1 mg.

Противопоказания: shock (including cardiogenic), acute heart failure and chronic insufficiency, severe bradycardia, cardiomegaly (without signs of heart failure), arterial hypotension (especially with myocardial infarction), bronchial asthma and chronic obstructive pulmonary disease in history, lactation period, age up to 18 years.

different dosage options, a pronounced effect for 24 hours.
is not an original drug, an extensive list of contraindications.

7. Egilok

The drug Egilok is not an equivalent replacement for Bisoprolol, as it contains metoprolol as an active ingredient. The main action of Egilok is aimed at lowering blood pressure and heart rate.

The drug is produced in tablets with a dosage of 25, 50 and 100 mg. The maximum effect is observed within 1-2 hours after administration. You need to take the tablets 2-3 times a day.

Противопоказания: heart failure in the stage of decompensation, cardiogenic shock, severe peripheral circulatory disorders, including with the threat of gangrene, acute myocardial infarction, breastfeeding, age up to 18 years.

fairly rapid therapeutic effect. It is used not only to treat angina pectoris and high blood pressure, but also ventricular extrasystole and supraventricular tachycardia.
short-term effect, it is necessary to take the drug 2 times a day.

8. Betalok ZOC

Another replacement is Bisaprolol, which contains metoprolol. Betaloc ZOK is available in the form of tablets, and its main action is to lower blood pressure. The maximum effect of the drug is felt within 3-4 hours after ingestion. Betaloc ZOK has a prolonged action, so it is taken once a day.

Противопоказания: AV block II and III degree, heart failure in the stage of decompensation, sinus bradycardia, cardiogenic shock, arterial hypotension, suspected acute myocardial infarction, age under 18 years.

a large list of indications for use (angina pectoris, hypertension, heart failure, migraine prophylaxis), valid for 24 hours.
possible side effects: bradycardia, fatigue, dizziness.

9. SotaGEKSAL

SotaGEKSAL contains sotalol and is available in the form of tablets with a dosage of 80 and 160 mg. Sotalol, although it belongs to beta-blockers, like bisoprolol, however, is mainly used as a drug with an antiarrhythmic effect and is prescribed for the prevention of atrial arrhythmias and the maintenance of sinus rhythm. It is necessary to take SotaGEKSAL 2-3 times a day.

fairly rapid therapeutic effect.
requires monitoring the patient’s condition on the ECG. Possible side effects: decrease in heart rate and blood pressure, increased sensitivity to the components of the drug.

10. Non-ticket

Nebilet contains the active substance nebivolol. The drug is produced in the form of tablets with a dosage of 5 mg. The main action of Nebilet is aimed at lowering blood pressure at rest and physical exertion, as well as during stress. The maximum effect occurs within 1-2 hours after taking the drug. You need to take Nebilet 1 time per day.

Противопоказания: acute heart failure, chronic heart failure in the stage of decompensation, severe arterial hypotension, bradycardia, cardiogenic shock, severe liver dysfunction, history of bronchospasm and bronchial asthma, depression, age under 18 years.

promotes the production of nitric oxide, therefore protects and strengthens the walls of blood vessels, quickly lowers blood pressure.
possible side effects: headache, dizziness, nausea.

How to choose an analogue of Bisoprolol

All of the above drugs, to one degree or another, are analogues of Bisoprolol. They differ in the severity and duration of the therapeutic effect, solubility in fats and water, as well as additional and side effects.3. Only a doctor can select an effective analogue of Bisoprolol, since each drug has its own characteristics of use, and the active substances are not interchangeable. For example, you cannot replace 10 mg of bisoprolol with 10 mg of nebivolol – this can seriously harm your health.

Reviews of doctors about analogues of Bisoprolol

Many cardiologists recommend the drug Concor, which effectively reduces the heart rate and causes virtually no side effects. It is convenient to select the dose of the drug, starting with the smallest, and then leave it for a long time4.

Doctors also recommend using Betalok ZOK. The drug effectively lowers blood pressure and is taken only 1 time per day.

At the same time, experts emphasize that despite the large number of analogues of Bisoprolol, only a doctor can choose the necessary drug.

Popular questions and answers

 We discussed important issues related to bisoprolol analogues with doctor of medical sciences, cardiologist Tatyana Brodovskaya.

Which patients are recommended bisoprolol?

– First of all, these are patients with angina pectoris, chronic heart failure. In this case, we observe a powerful positive effect on the prognosis of mortality prevention, as well as a decrease in the frequency of dangerous complications (for example, myocardial infarction). But in the treatment of arterial hypertension, this class of drugs is less in demand today, although it is listed in the registered indications.

What happens if you stop using Bisoprolol and switch to an analogue?

– The first thing that is important to pay attention to is that beta-blockers are not recommended to be canceled abruptly. Cancellation should be gradual and under medical supervision.

Side effects such as bradycardia, the development of atrioventricular blockade, pressure reduction directly depend on the dosage of the drug. Therefore, if side effects appear, you can discuss with your doctor the issue of reducing the dosage, and not completely abolishing it.

The selection of an analogue and replacement of bisoprolol cannot be dealt with independently. Only a doctor will take into account all the features of the patient’s clinical situation: the presence of left ventricular hypertrophy, dyslipidemia, the state of liver and kidney function, arrhythmias, and then individually select the necessary beta-blockers.

  1. Shlyakhto E.V. Cardiology: a national guide. M., 2021. https://www.rosmedlib.ru/book/ISBN9785970460924.html
  2. clinical standards. Cardiology. E.V. Reznik, I.G. Nikitin. M., 2020. https://www.studentlibrary.ru/book/ISBN9785970458518.html
  3. Клинические рекомендации «Хроническая сердечная недостаточность у взрослых». 2018 – 2020. https://diseases.medelement.com/disease/%D1%85%D1%80%D0%BE%D0%BD%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F-%D1%81%D0%B5%D1%80%D0%B4%D0%B5%D1%87%D0%BD%D0%B0%D1%8F-%D0%BD%D0%B5%D0%B4%D0%BE%D1%81%D1%82%D0%B0%D1%82%D0%BE%D1%87%D0%BD%D0%BE%D1%81%D1%82%D1%8C-%D1%83-%D0%B2%D0%B7%D1%80%D0%BE%D1%81%D0%BB%D1%8B%D1%85-%D0%BA%D1%80-%D1%80%D1%84-2020/17131
  4. 2000-2022. REGISTER OF DRUGS OF RUSSIA® RLS https://www.rlsnet.ru/

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